垂体类器官的研究进展与展望

Research progress and prospects of pituitary organoids

垂体是人体最重要的内分泌器官之一,在维持机体内环境稳态中发挥着关键作用。类器官作为一种新型体外研究模型,已在发育生物学、再生医学、疾病建模、个体化精准医疗等方面得到广泛应用。近年来干细胞衍生的垂体类器官为垂体疾病的研究提供了良好的实验模型,并为垂体疾病的再生医学治疗研究提供了新思路。该文主要就垂体类器官的现有构建系统和应用研究进展进行综述。

The pituitary gland is one of the most important endocrine organs in the human body and plays a key role in maintaining the homeostasis of the internal environment.Organoids,as a new type of in vitro research model,have been widely used in developmental biology,regenerative medicine,disease modeling,personalized precision medicine and other fields.In recent years,pituitary organoids derived from stem cells have provided a good experimental model for the research on pituitary diseases,and led to novel ideas for the research on treatment of pituitary diseases with regenerative medicine.This review focus on the advances in construction and applications of pituitary organoids.