基于玄府与水通道蛋白的相关性探讨抑郁症的病机治法

Exploring in the pathogenesis and treatment of depression based on the correlation between Xuanfu and aquaporin

玄府是中医学中的一个微观概念,分布广泛,具有流通气液、渗灌血脉、运转神机的重要功能,笔者认为玄府郁闭会造成气机升降失调、液停痰凝、神机不用,从而导致抑郁症的发生;水通道蛋白是一种小分子跨膜运输蛋白,可以通过水、甘油、尿素以及二氧化碳等,广泛存在于中枢和外周系统,可以通过调节星形胶质细胞的功能以及其他方式参与抑郁症的发生发展。文章基于两者在结构、功能上的相似性,与在抑郁症发病中的参与度,探讨抑郁症的病因病机及治疗,为进一步认识玄府理论和在抑郁症中的应用提供理论依据。

Xuanfu is a microcosmic concept in traditional Chinese medicine.It is widely distributed and has the important functions of circulating qi and fluid,infiltrating blood vessels and transporting spiritual mechanism.The authors believe that Xuanfu depression will cause the imbalance of the rise and fall of qi,the stagnation of liquid and the coagulation of phlegm and the disuse of divine machines,which will lead to the occurrence of depression.Aquaporin are water channel proteins that facilitate the flux of water through the plasma membrane,which can transport water,glycerol,urea,and gases such as carbon dioxide,and it is widely present in the central and peripheral areas.Some subtypes can be involved in the development of depression by regulating the function of astrocytes and in other ways.Based on their similarities in structure and function and their participation in the pathogenesis of depression,this paper discussed the etiology,pathogenesis and treatment of depression,so as to provide a theoretical basis for further understanding of Xuanfu theory and its application in depression.