头颈部腺样囊性癌预后分析:单中心经验

Prognosis of adenoid cystic carcinoma in head and neck region:a single-centre experience

目的:通过探讨头颈部腺样囊性癌(adenoid cystic carcinoma,ACC)的临床特点,分析影响其生存、复发、转移等预后的因素。方法:回顾性收集2010年1月—2020年12月在山东第一医科大学附属省立医院口腔颌面外科就诊的188例腺样囊性癌患者的临床资料,进行门诊或电话随访,采用SPSS 26.0软件包中的Kaplan-Meier法评估生存情况,应用Cox回归分析对其相关预后因素进行分析。结果:188例患者总体生存率为76.6%,其中因复发死亡13.3%,远处转移死亡10.1%。复发率23.9%,转移率10.1%。其中复发患者生存率42.2%,转移患者生存率为68.4%。Cox回归分析结果显示,年龄、肿瘤原发灶大小、区域淋巴结转移和治疗方式为影响患者生存率的预后因素。结论:患者年龄、T分期、N分期和治疗方式为影响腺样囊性癌患者生存率的预后因素,患者年龄、神经侵犯为影响腺样囊性癌患者复发的预后因素,患者N分期为影响腺样囊性癌患者转移的预后因素。

PURPOSE:To explore the prognostic factors of adenoid cystic carcinoma(ACC)in head and neck region by analyzing associated clinical characters.METHODS:A total of 188 patients with ACC in head and neck region were enrolled,and the follow-up was carried out by outpatient review or telephone.Kaplan-Meier method was used to assess the survival rates,and Cox regression analysis was used to identify the associated prognostic factors with SPSS 26.0 software package.RESULTS:The overall survival rate of 188 patients was 76.6%,of which 13.3%died of recurrence and 10.1%died of distant metastasis.The rate of local recurrence and distant metastasis were 23.9%and 10.1%,of which the survival rate was 42.2%and 68.4%,respectively.Cox regression analysis revealed that age,T stage,N stage,and regimens were significantly associated with survival of ACC.CONCLUSIONS:In ACC,age,T stage,N stage,and regimen were independent prognostic factors of survival,age and nerve invasion were independent prognostic factors of recurrence,and N stage was independent prognostic factor of distant metastasis.