椎基底动脉延长扩张症的动物模型

Animal models of vertebrobasilar dolichoectasia

椎基底动脉延长扩张症(vertebrobasilar dolichoectasia,VBD)是一种脑血管变异性疾病。研究表明,VBD进一步发展会造成严重残疾甚至死亡。VBD的发病机制至今仍不明确,临床尚无特异性防治方案。因此,建立稳定可靠的动物模型有助于进一步了解VBD的病理生理学机制和潜在治疗靶点。文章对现有VBD动物模型的建立方法和研究进展进行了综述。

Vertebrobasilar dolichoectasia(VBD)is a cerebrovascular variant disease.Researches have shown that further development of VBD may lead to severe disability and even death.The pathogenesis of VBD is still unclear,and there is no specific clinical prevention and treatment scheme.Therefore,establishing a stable and reliable animal model helps to further understand the pathophysiological mechanisms and potential therapeutic targets of VBD.This article reviews the establishment methods and research progress of the available VBD animal models.