女性男性化肾上腺皮质癌1例报告

Female masculinization adrenal cortical carcinoma:a case report

肾上腺皮质癌(ACC)是罕见的神经内分泌肿瘤,起病隐匿、进展快,成人往往以腹|部包块疼痛就诊。ACC兼具内分泌肿瘤特点,其表现为女性明显男性化者则较为少见。本文报道1例,该女性因出现男性化体征、腹部巨大包块就诊,多学科讨论后予后腹膜肿物切除术,病理诊断为ACC。术后予依托泊苷+卡铂辅助化疗6周期,术后随访6个月未见转移、复发。

Adrenal cortical carcinoma(ACC)is a rare neuroendocrine tumor with concealed onset and rapid progression.Adults often seek treatment with abdominal mass pain.ACC has the characteristics of endocrine tumor,but its obvious masculinization in women is relatively rare.This article reports a case of a woman who presented with signs of androgenesis and a large abdominal mass.After multidisciplinary discussions,a retroperitoneal mass resection was performed,and a pathological diagnosis of adrenal cortical cancer was made.After the surgery,etoposide and carboplatin were used as adjuvant chemotherapy for 6 cycles.No metastasis or recurrence was found after a follow-up of 6 months.