新型冠状病毒感染疾病症状与衰弱的相关性研究

Study on the correlation between symptoms of coronavirus disease 2019 and frailty

目的了解新型冠状病毒感染(以下简称“新冠感染”)者衰弱现状,分析新冠感染对衰弱发生的影响。方法采用横断面调查方法,选取2022年11月-12月入住广州某集中隔离点的新冠感染者进行“问卷星”在线问卷调查,其中包括一般情况、Tilburg衰弱量表(Tilburg Frailty Indicator,TFI)、新冠感染症状评分、心理弹性量表。采用多模型logistic回归分析探究新冠感染对衰弱发生的影响。结果共发放调查问卷667份,其中有效问卷594份,有效回收率为89.1%,新冠感染后新发生衰弱51例(8.6%)。在调查的594例患者中,150例(25.3%)处于衰弱状态,444例(74.7%)处于非衰弱状态。新冠感前TFI评分中位数为3(2,4)分,16.7%(99/594)处于衰弱状态;新冠感染后TFI评分中位数为3(2,5)分,25.3%(150/594)处于衰弱状态;新冠感染前后TFI评分(Z=-6.596,P<0.001)、衰弱发生率(χ^(2)=351.648,P<0.001)比较,差异均有统计学意义。多因素logistic回归分析结果显示,校正疾病因素、人口学因素、心理因素后,新冠感染症状评分始终是新冠感染者衰弱影响因素;新冠感染症状评分整体变化趋势有统计学意义(P趋势<0.001)。结论新冠感染症状评分是新冠感染者发生衰弱的重要危险因素或预测因子,随着新冠感染症状评分水平的升高,新冠感染者衰弱风险随之增加。

Objective To investigate the status of frailty in patients with coronavirus disease 2019(COVID-19),and to analyze the influence of COVID-19 disease on the prevalence of frailty.Methods This study was conducted using a cross-sectional survey method.COVID-19 patients admitted to a centralized isolation point in Guangzhou were selected for an questionnaire survey by“questionnaire star”,between November and December 2022.The questionnaire included the general information questionnaire,Tilburg Frailty Indicator(TFI),the COVID-19 symptom scale and Mental Resilience Scale(RS-11).Multi-model logistic regression analysis was used to explore the influence of COVID-19 on the occurrence of debilitation.Results A total of 667 questionnaires were distributed,of which 594 were valid,with an effective rate of 89.1%.There were 150 patients(25.3%)were frail,444 patients(74.7%)were non-frail,and 51 patients(8.6%)were newly frail after infected COVID-19.The median TFI score before COVID-19 was 3(2,4)points,16.7%(99/594)were in a weak state.The median TFI score after COVID-19 was 3(2,5)points,25.3%(150/594)were in a weak state.There were statistically significant differences in TFI scores(Z=−6.596,P<0.001)and the incidence of debilitation(χ^(2)=351.648,P<0.001)before and after COVID-19.The results of multivariate logistic regression analysis showed that after controlling disease factors,demographic factors and psychosocial factors,the score of the COVID-19 symptom score was always the influencing factor of COVID-19 patients.The overall change trend of COVID-19 symptom score was statistically significant(P<0.001).Conclusions The COVID-19 symptom score is an important risk factor or predictor of frailty in patients with COVID-19.As the level of COVID-19 symptom score increases,the risk of frailty in COVID-19 patients increases.