成人脓毒症分型研究进展

Research progress on phenotyping of adult sepsis

脓毒症是一种严重的高发疾病,整体病死率偏高。脓毒症的临床表现存在高度异质性,且通常合并全身多脏器功能障碍,因此其救治仍存在诸多挑战。理想的脓毒症治疗应该基于患者的疾病分型,对其具体分型进行针对性治疗。本文将国内外涉及脓毒症分型的研究进行归纳,从相关定义、研究方法、现有的分型依据(如基于分子机制、病理生理机制、临床表现等),以及未来可能出现的新分型等方面概述脓毒症分型的研究进展,以期为将来新亚型的发现及针对脓毒症亚型救治的基础和临床研究提供思路。

Sepsis is a serious disease with high incidence and mortality.The pathogenesis,clinical manifestations,and multiple organ dysfunction of sepsis are complex and diverse,and this high heterogeneity leads to many challenges in the treatment of sepsis.The ideal treatment of sepsis should be based on its subphenotypes and targeted to the specific one.This review summarizes the research progress on phenotyping of adult sepsis from the relevant definitions,research methods,existing subtypes(such as based on molecular mechanism,pathophysiological mechanism,clinical manifestations,etc.),and the possible new subtypes in the future.We expect to flash a light on the discovery of new subtypes and the basic clinical research for the treatment of septic subtypes through this paper.