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PD-1抑制剂联合FOLFOX治疗晚期胃癌患者的效果研究

Effect of PD-1 Inhibitor Combined with FOLFOX in the Treatment of Patients with Advanced Gastric Cancer
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摘要 目的:探讨PD-1抑制剂联合奥沙利铂与5-氟尿嘧啶(FOLFOX)治疗对晚期胃癌患者机体免疫及血清肿瘤标志物水平的影响。方法:选取2020年10月—2021年10月本院收治的90例晚期胃癌患者,按随机数字表法分为对照组及观察组,每组45例。对照组给予FOLFOX化疗方案治疗,观察组在此基础上联合PD-1抑制剂治疗,比较两组疗效、免疫功能指标[白细胞分化抗原(CD)3^(+)、CD4^(+)、CD8^(+)]、血清肿瘤标志物[糖类抗原(CA)125、CA199、癌胚抗原(CEA)]。结果:观察组ORR、DCR分别为71.11%、91.11%,均高于对照组的48.89%、66.67%(P<0.05);两组治疗后CD3^(+)、CD4^(+)高于治疗前,CD8^(+)低于治疗前,且观察组CD3^(+)、CD4^(+)高于对照组,CD8^(+)低于对照组(P<0.05);两组治疗后CA199、CA125、CEA水平低于治疗前,且观察组低于对照组(P<0.05)。结论:晚期胃癌患者应用PD-1抑制剂联合FOLFOX治疗可获确切疗效,改善免疫功能,并降低肿瘤标志物水平。 Objective:To investigate the effect of PD-1 inhibitor combined with oxaliplatin and 5-fluorouracil(FOLFOX)on immune function and serum tumor markers in patients with advanced gastric cancer.Methods:A total of 90 patients with advanced gastric cancer admitted to our hospital from October 2020 to October 2021 were randomly divided into control group and observation group,with 45 cases in each group.The control group was treated with FOLFOX chemotherapy regimen,and the observation group was treated with PD-1 inhibitor on this basis.The efficacy,immune function indexes[white blood cell differentiation antigen(CD)3^(+),CD4^(+),CD8^(+)],and serum tumor markers[carbohydrate antigen(CA)125,CA199,and carcinoembryonic antigen(CEA)]were compared between the two groups.Results:ORR and DCR in the observation group were 71.11%and 91.11%,respectively,which were higher than 48.89%and 66.67%in the control group(P<0.05).After treatment,CD3^(+)and CD4^(+)in the two groups were higher than those before treatment,CD8^(+)was lower than that before treatment,and CD3^(+)and CD4^(+)in the observation group were higher than those in the control group,CD8^(+)was lower than that in the control group(P<0.05).The levels of CA199,CA125 and CEA in the two groups after treatment were lower than those before treatment,and those in the observation group were lower than the control group(P<0.05).Conclusion:PD-1 inhibitor combined with FOLFOX can achieve definite curative effect,improve immune function and reduce tumor marker levels in patients with advanced gastric cancer.
作者 石少庆 张学良 SHI Shaoqing;ZHANG Xueliang(The Fifth Department of Oncology,Jiamusi Tumor Tuberculosis Hospital,Jiamusi 154007,Heilongjiang,China)
出处 《中国药物滥用防治杂志》 CAS 2023年第9期1599-1602,共4页 Chinese Journal of Drug Abuse Prevention and Treatment
关键词 晚期胃癌 PD-1抑制剂 奥沙利铂与5-氟尿嘧啶 血清肿瘤标志物 免疫功能 Advanced gastric cancer PD-1 inhibitor Oxaliplatin and 5-fluorouracil Serum tumor markers Immune function
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