摘要
阿尔茨海默病(AD)是一种慢性神经退行性疾病。目前临床治疗AD的药物只能改善其症状,不能治愈。本文结合AD的发病机制和病理改变,在抗β-淀粉样蛋白沉积、消除高度磷酸化tau蛋白、改变炎症状态、改善微血管病变、保护血脑屏障、纠正代谢紊乱等治疗措施方面,综述近年来AD药物治疗的进展,为AD综合治疗提供研究依据。
Alzheimer's disease(AD)is a chronic neurodegenerative disorder characterized by progressive cognitive decline.Presently,the pharmaceutical interventions employed in clinical settings merely alleviate the symptoms of AD,without offering a definitive cure.Taking into consideration the pathogenesis and pathological pathways associated with AD,this paper conducts a comprehensive review of recent advancements in drug therapies for AD.These advancements encompass multiple therapeutic approaches,such as targeting the reduction ofβ-amyloid deposition,clearance of highly phosphorylated tau protein,modulation of inflammatory processes,amelioration of microangiopathy,safeguarding the integrity of the blood-brain barrier,rectifying metabolic dysfunctions,and other related measures.The intention behind this review is to furnish a solid foundation for further research and development,ultimately aiming towards a comprehensive approach for the treatment of AD.
作者
翟雅莉
贾新
王晓明
Zhai Yali;Jia Xin;Wang Xiaoming(The Fifth Outpatient Department,986 Hospital,Xijing Hospital,Air Force Medical University,Xi'an 710061;Department of Geriatics,Xijing Hospital,Air Force Medical University,Xi'an 710032)
出处
《国际老年医学杂志》
2023年第5期605-608,共4页
International Journal of Geriatrics
基金
国家重点研发计划项目(2020YFC2008000)。
关键词
阿尔茨海默病
机制
治疗
Alzheimer's disease
Pathogenesis
Treatment