阿尔茨海默病的药物治疗进展

Emerging Frontiers in Drug Therapies for Alzheimers Disease

阿尔茨海默病(AD)是一种慢性神经退行性疾病。目前临床治疗AD的药物只能改善其症状,不能治愈。本文结合AD的发病机制和病理改变,在抗β-淀粉样蛋白沉积、消除高度磷酸化tau蛋白、改变炎症状态、改善微血管病变、保护血脑屏障、纠正代谢紊乱等治疗措施方面,综述近年来AD药物治疗的进展,为AD综合治疗提供研究依据。

Alzheimer's disease(AD)is a chronic neurodegenerative disorder characterized by progressive cognitive decline.Presently,the pharmaceutical interventions employed in clinical settings merely alleviate the symptoms of AD,without offering a definitive cure.Taking into consideration the pathogenesis and pathological pathways associated with AD,this paper conducts a comprehensive review of recent advancements in drug therapies for AD.These advancements encompass multiple therapeutic approaches,such as targeting the reduction ofβ-amyloid deposition,clearance of highly phosphorylated tau protein,modulation of inflammatory processes,amelioration of microangiopathy,safeguarding the integrity of the blood-brain barrier,rectifying metabolic dysfunctions,and other related measures.The intention behind this review is to furnish a solid foundation for further research and development,ultimately aiming towards a comprehensive approach for the treatment of AD.