艾塞那肽临床应用的研究进展

Research Progress of Exenatide in Clinical Application

胰高血糖素样肽-1受体激动剂(GLP-1 RAs)-艾塞那肽是一种作用机制全新的降糖药物,广泛用于治疗2型糖尿病(T2DM)。艾塞那肽的降糖作用具有葡萄糖浓度依赖性,且改善胰腺β细胞功能,除降糖作用外,艾塞那肽还可减轻体质量、降低血压、调节血脂,具有心血管安全性。艾塞那肽也可治疗1型糖尿病,对帕金森病及多囊卵巢综合征患者也有一定益处。本文对艾塞那肽除降糖以外的作用,如减轻体质量、降低血压、改善血脂代谢、心血管安全性及在其他疾病中应用的研究进展作一综述。

Glucagon-like peptide-1 receptor agonists(GLP-1 RAs),particularly exenatide,represent a novel class of hypoglycemic agents widely employed in the management of type 2 diabetes mellitus(T2DM).The glucose-lowering efficacy of exenatide is contingent upon the concentration of circulating glucose.Notably,this agent enhances the function of pancreatic beta cells,while concurrently exhibiting favorable cardiovascular outcomes by promoting weight loss,reducing blood pressure,and modulating blood lipid levels.Moreover,exenatide demonstrates potential applicability in the treatment of type 1 diabetes,as well as offering certain advantages for patients with Parkinson's disease and polycystic ovary syndrome.This comprehensive review article critically examines the advancements in exenatide research,encompassing its efficacy in weight loss,blood pressure reduction,regulation of blood lipid metabolism,cardiovascular safety,and its potential utility in diverse medical conditions.