儿童特应性皮炎患儿血清IP-10和CXCR3水平及临床意义

Serum levels of IP-10 and CXCR3 in children with atopic dermatitis and their clinical significance

目的 探讨儿童特应性皮炎(AD)患儿血清干扰素-γ诱导蛋白-10(IP-10)和趋化因子受体3(CXCR3)水平及临床意义。方法 选取2020年3月至2022年3月在该院诊断为AD的114例患儿作为AD组,根据特应性皮炎评分(SCORAD)分为轻度组(38例)、中度组(42例)、重度组(34例);同期选择在该院体检健康的108例儿童作为对照组。采用酶联免疫吸附试验(ELISA)检测血清IP-10和CXCR3水平,Pearson法分析AD患儿血清IP-10和CXCR3的相关性,绘制受试者工作特征(ROC)曲线分析IP-10、CXCR3对AD的诊断价值。结果 与对照组比较,AD组血清IP-10和CXCR3水平均升高(P<0.05);重度组的IP-10、CXCR3水平和SCORAD评分均高于中度组和轻度组(P<0.05),中度组高于轻度组(P<0.05);相关性分析显示,AD组血清IP-10和CXCR3水平呈正相关(P<0.05);ROC曲线分析显示,二者联合诊断AD的曲线下面积大于IP-10和CXCR3单项诊断(P<0.05)。结论 AD患儿血清IP-10和CXCR3水平均升高,二者联合对AD具有一定的诊断价值。

Objective To investigate the serum levels of interferon-γ-inducible protein-10(IP-10)and chemokine receptor 3(CXCR3)in children with atopic dermatitis(AD)and their clinical significance.Methods From March 2020 to March 2022,a total of 114 children diagnosed with AD in this hospital were selected as the AD group.and they were divided into mild group(38 cases),moderate group(42 cases)and severe group(34 cases)according to SCORAD score.In the same period,108 healthy children in the hospital were selected as control group.Serum levels of IP-10 and CXCR3 were detected by enzyme-linked immunosorbent assay(ELISA),the correlation between serum IP-10 and CXCR3 in children with AD was analyzed by Pearson method,and receiver operating characteristic(ROC)curve was drawn to analyze the diagnostic value of IP-10 and CXCR3 in AD.Results Compared with the control group,the expression of serum IP-10 and CXCR3 in AD group significantly increased(P<0.05).The levels of IP-10,CXCR3 and SCORAD score in severe group were significantly higher than those in moderate and mild groups(P<0.05),and those in the moderate group was significantly higher than those in mild group(P<0.05).Correlation analysis showed that the levels of serum IP-10 and CXCR3 in AD group were positively correlated(P<0.05).ROC curve analysis showed that the area under the curve of the combined diagnosis of AD was greater than that of IP-10 and CXCR3 alone(P<0.05).Conclusion Serum levels of IP-10 and CXCR3 significantly increase in children with AD,and the combination of the two has certain diagnostic value for AD.