复发转移性腺样囊性癌的治疗进展

Progress in the Treatment of Recurrent or Metastatic Adenoid Cystic Carcinoma

腺样囊性癌(adenoid cystic carcinoma,ACC)是一种罕见的,惰性但又具有侵袭性的恶性肿瘤。在根治性治疗后复发和远处转移很常见,并且缺乏有效的治疗方式,这使得复发或转移性ACC(recurrent or metastatic adenoid cystic carcinoma,RM-ACC)的长期预后较差。在这篇综述中,我们介绍了最新的临床病理特征、分子分型和治疗进展,以更好地指导临床治疗和改善RM-ACC的预后。

Adenoid cystic carcinoma(ACC)is a rare,indolent,but aggressive malignant tumor.Common recurrence and distant metastases after curative-intent treatment,as well as lack of effective treatment,make the long-term prognosis of recurrent or metastatic ACC(RM-ACC)very poor.In this review,we present an update of clinicopathologic features,molecular classification and current progress in treatment,so as to better guide clinical management and improve the outcome of RM-ACC.