中国拉祜族PP1PK血型频率调查

Frequency survey of blood group PP1PK in Chinese Lahu Population

目的 了解中国拉祜族人群中P1PK血型和GLOB血型表现频率,掌握拉祜族人群遗传现状。掌握该类血型表现型频率可为患者临床输血安全提供数据支撑,为孕妇提供妊娠建议及用血指导。方法 随机抽取中国拉祜族人群无关个体,进行P1PK、P血型血清学鉴定及基因测序分析,分析P1PK血型和GLOB血型表现频率。结果 从300名拉祜族人群中检出6例抗-PP1Pk(原抗-Tja,以下均称抗-PP1Pk)反应阴性血型,鉴定为罕见的P1-PK-P-血型(原称Tja-血型或p血型,以下均称为p血型)。拉祜族人群P1PK、GLOB血型系统中p血型表型频率为2.0%(6/300)。结论 拉祜族人群p血型表型频率明显高于欧州(5.8人/每百万人)和中国香港地区(1人/每百万人),存在显蓍的民族特异性和地域种族差异性。

Objective To investigate the frequency of P1PK and GLOB blood group in Chinese Lahu population and their genetic status,so as to provide data support for the safety of blood transfusion and give advice and transfusion guidance for pregnant women.Methods Unrelated individuals of Chinese Lahu population were randomly selected for serological i⁃dentification of P1PK and P blood group and gene sequencing analysis.The frequency of P1PK and GLOB blood group were analyzed.Results Six cases of anti⁃PP1Pk(formerly known as anti⁃Tja)negative blood type were identified as the rare P1⁃PK⁃P⁃blood type(formerly known as Tja⁃blood type or p blood type,hereinafter referred to as p blood group)from 300 Lahu population,with phenotypic frequency of p blood group in P1PK and GLOB blood group system in Lahu population at 2.0%(6/300).Conclusion The phenotypic frequency of blood group p in Lahu population was significantly higher than that in Europe(5.8 persons per million)and Hong Kong,China(1 person per million),indicating significant ethnic specificity and regional ethnic differences.