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乳腺癌干细胞在乳腺癌内分泌治疗耐药中的作用研究进展 被引量：1

The research process of breast cancer stem cells in endocrine therapy resistance of breast cancer
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摘要 乳腺癌干细胞(breast cancer stem cells,BCSCs)是存在于乳腺癌组织中的数量很少、具有自我更新能力和产生异质性肿瘤细胞的细胞亚群。内分泌耐药是目前内分泌治疗应用的主要限制。现有研究表明,BCSCs在乳腺癌内分泌治疗耐药中发挥重要作用。本文就BCSCs在激素受体(hormone receptor,HR)阳性乳腺癌内分泌治疗耐药中的作用进行综述。 Breast cancer stem cells(BCSCs)represent a small subpopulation of tumor cells that can self-renew and generate tumor heterogeneity.Currently,endocrine resistance is a obstacle in endocrine therapy of patients with hormone receptor(HR)positive breast tumours.Existing studies provide evidence that BCSCs play an important role in endocrine therapy resistance in breast cancer.This article reviews the role of BCSCs in endocrine therapy resistance in HR+breast cancer.
作者 张浩 李玉凤 胡万宁 ZHANG Hao;LI Yufeng;HU Wanning(Graduate Institute of North China University of Science and Technology,Hebei Tangshan 063210,China;The Center Institute of Tangshan People's Hospital,Hebei Tangshan 063001,China;Tangshan Workers Hospital,Hebei Tangshan 063003,China)
机构地区 华北理工大学研究生院 唐山市人民医院中心实验室 唐山工人医院
出处 《现代肿瘤医学》 CAS 北大核心 2023年第19期3702-3706,共5页 Journal of Modern Oncology
基金 河北省分子肿瘤学重点实验室项目(编号:SZX2020043)。
关键词 激素受体阳性乳腺癌 内分泌治疗耐药 乳腺癌干细胞 hormone receptor positive breast cancer endocrine therapy resistance breast cancer stem cells
分类号 R737.9 [医药卫生—肿瘤]
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  • 1Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet 2005; 365: 1687-717.
  • 2A1-Hajj M, Wicha MS, Benito-Hernandez A, Morrison S J, Clarke MF. Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A 2003; 100: 3983-8.
  • 3Patrawala L, Calhoun T, Schneider-Broussard R, Zhou J, Claypool K, Tang DG. Side population is enriched in tu- morigenic, stem-like cancer cells, whereas ABCG2+ and ABCG2- cancer cells are similarly tumorigenic. Cancer Res 2005; 65: 6207-19.
  • 4Ricci-Vitiani L, Lombardi DG, Pilozzi E, Biffoni M, Todaro M, Peschle C, et al. Identification and expansion of human colon-cancer-initiating cells. Nature 2007; 445: 111-5.
  • 5Fillmore CM, Kuperwasser C. Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemo- therapy. Breast Cancer Res 2008; 10: R25.
  • 6Li X, Lewis MT, Huang J, Gutierrez C, Osborne CK, Wu MF, et al. Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy. J Natl Cancer lnst 2008; 100: 672-9.
  • 7Asselin-Labat ML, Shackleton M, Stingl J, Vaillant F, Forrest NC, Eaves CJ, et al. Steroid hormone receptor status of mouse mammary stem cells. J Natl Cancer Inst 2006; 98: 1011-4.
  • 8Sleeman KE, Kendrick H, Robertson D, Isacke CM, Ashworth A, Smalley MJ. Dissociation of estrogen re- ceptor expression and in vivo stem cell activity in the mammary gland. J Cell Bio12007; 176: 19-26.
  • 9Warri AM, Laine AM, Majasuo KE, Alitalo KK, Harko- nen PL. Estrogen suppression of erbB2 expression is associated with increased growth rate of ZR-75-1 human breast cancer cells in vitro and in nude mice. Int J Can- cer 1991; 49: 616-23.
  • 10McClelland RA, Barrow D, Madden TA, Dutkowski CM, Pamment J, Knowlden JM, et al. Enhanced epi-dermal growth factor receptor signaling in MCF7 breast cancer cells after long-term culture in the presence of the pure antiestrogen ICI 182,780 (Faslodex). Endocrinol- ogy 2001; 142: 2776-88.

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现代肿瘤医学
2023年 第19期

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