基于肺-肠轴浅析脓毒症急性肺损伤的针刺思路

Analysis of Acute Lung Injury in Sepsis Based on Lung-Intestinal Axis

近年来肠道菌群的研究备受研究者们青睐,已有大量研究证明肠道菌群与人体健康密切相关。由肠道菌群介导的各种通路更是在疾病发生发展中起着重要作用,其中“脑-肠轴”,不管是上行通路-由肠治脑,还是下行通路-从脑治肠已有大量报道。而近几年,关于“肺-肠轴”的研究也逐渐兴起,这是对祖国医学“肺与大肠相表里”理论的现代更深层次研究。针刺作为祖国医学最具特色的治疗手段,它对疾病的治疗能力逐渐被挖掘。在现代研究中,一方面,相关报道证实肺-肠之间可能通过相关微生物区系、黏膜、免疫、神经内分泌等层面存在一定联系;另一方面,针刺对肠道菌群具有调节作用。再者,相关研究也表明针刺可以对脓毒症诱导的急性肺损伤症状发挥改善作用。因此,文章以从肠论治为切入点,基于“肺-肠轴”理论探讨针刺治疗脓毒症诱导的急性肺损伤的相关思路。

In recent years,the study of intestinal flora has been favored by researchers,and a large number of studies have proved that intestinal flora is closely related to human health.Various pathways mediated by intestinal flora play an important role in the occurrence and development of the disease,among which the"brain-gut axis",whether it is the ascending pathway-from the intestine to the brain,or the descending pathway-from the brain to the intestine has been widely reported.In recent years,the research on the"lung-intestine axis"has also gradually emerged,which is a modern and deeper study of the theory of"lung and large intestine"in the motherland's medicine.As the most characteristic treatment method of medicine in the motherland,acupuncture has gradually tapped its ability to treat diseases.In modern research,on the one hand,relevant reports confirm that there may be a certain connection among the lungs and intestines through related microflora,mucosa,immunity,neuroendocrine and other levels.On the other hand,acupuncture has a regulating effect on the intestinal flora,and studies have shown that acupuncture can improve the symptoms of sepsis-induced acute lung injury.Therefore,this paper takes the intestinal treatment as the starting point and discusses the relevant ideas of acupuncture in the treatment of sepsis-induced acute lung injury based on the"lung-gut axis"theory.