ADAMDEC1蛋白在脑膜瘤中的表达及意义

Expression and significance of ADAMDEC1 protein in meningiomas

目的检测脑膜瘤组织中崩解素和金属蛋白酶结构域样蛋白decysin-1(a disintegrin and metalloproteases-like decysin-1,ADAMDEC1)的表达,探讨其与脑膜瘤病理特征的相关性。方法收集2015年7月至2017年12月在西南医科大学附属中医医院神经外科住院并行手术切除治疗、病理诊断结果为脑膜瘤的脑膜瘤组织标本32例,设为脑膜瘤组;同期取自重型颅脑外伤行内外减压术的正常脑组织标本12例,设为对照组。应用免疫组织化学法检测ADAMDEC1的表达。结果ADAMDEC1蛋白在脑膜瘤组织中的表达显著高于正常脑膜组织,差异均有统计学意义(P<0.05)。脑膜瘤WHO分级与ADAMDEC1的表达呈正相关,差异均有统计学意义(P<0.05)。脑膜瘤的侵袭性与ADAMDEC1蛋白表达呈正相关,差异均有统计学意义(P<0.05)。结论ADAMDEC1在脑膜瘤组织中高表达,其阳性表达高低与脑膜瘤WHO分级、脑膜瘤的侵袭性存在关联,ADAMDEC1可作为脑膜瘤恶性程度分级评判指标,ADAMDEC1蛋白检测在脑膜瘤患者的诊断和预后中具有重要意义。

Objective To detect the expression of a disintegrin and metalloproteases-like decysin-1(ADAMDEC1)in meningioma tissue and explore its correlation with the pathological characteristics of meningioma.Methods From July 2015 to December 2017,32 cases of meningioma tissue samples were collected from Department of Neurosurgery,the Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University and were treated with surgical resection;At the same time,12 normal brain tissue samples were taken from severe craniocerebral trauma patients undergoing internal and external decompression,and were set as control group.The expression of ADAMDEC1 was detected by immunohistochemistry.Results The expression of ADAMDEC1 protein in meningioma tissue was significantly higher than that in normal meningioma tissue(P<0.05).The WHO grade of meningioma was positively correlated with the expression of ADAMDEC1,and the difference was statistically significant(P<0.05).The invasiveness of meningioma was positively correlated with the expression of ADAMDEC1 protein,and the difference was statistically significant(P<0.05).Conclusion ADAMDEC1 is highly expressed in meningioma tissue,and its positive expression level is correlated with the WHO grade of meningioma and the invasiveness of meningioma.ADAMDEC1 can be used as an index to evaluate the malignant grade of meningioma,and the detection of ADAMDEC1 protein has important significance in the diagnosis and prognosis of meningioma patients.