Myo、cTnI、hs-CRP联合检测在急性心肌梗死中的应用价值

Significance of combined detection of Myo,cTnI and hs-CRP for acute myocardial infarction

目的探讨肌红蛋白(Myo)、心肌肌钙蛋白I(cTnI)、高敏C反应蛋白(hs-CRP)联合检测在急性心肌梗死中的应用价值。方法抽取2021年11月至2022年10月聊城市第三人民医院收治的120例急性心肌梗死患者作为研究组,另抽取同期健康体检者120例作为对照组。比较两组及研究组中不同时间点、不同预后患者的血清Myo、cTnI、hs-CRP水平,分析各项指标的诊断阳性率及其与急性心肌梗死预后的相关性。结果研究组血清Myo、cTnI、hs-CRP水平高于对照组(P<0.05)。研究组急性心肌梗死患者入院时血清Myo、cTnI、hs-CRP水平较高,随着入院治疗时间延长,各项指标水平出现下降趋势。研究组中预后较差者血清Myo、cTnI、hs-CRP水平高于预后良好者(P<0.05)。120例急性心肌梗死患者中Myo、cTnI、hs-CRP三项指标联合诊断准确率(97.50%,117/120)高于单项指标(83.33%,108/120;87.50%,105/120;89.17%,107/120,P<0.05)。Myo、cTnI、hs-CRP水平与急性心肌梗死预后呈正相关(r=0.75、0.35、0.42,P均<0.05)。结论Myo、cTnI、hs-CRP联合检测对急性心肌梗死有一定的诊断价值,且能判断患者预后情况。

Objective To investigate the significance of combined detection of myoglobin(Myo),cardiac troponin I(cTnI),and high-sensitivity C-reactive protein(hs-CRP)for acute myocardial infarction.Methods A total of 120 patients with acute myocardial infarction admitted to Liaocheng Third People’s Hospital from November 2021 to October 2022 were selected as the research group,and 120 healthy people who underwent physical examination during the same period were selected as the control group.The levels of Myo,cTnI and hs-CRP were compared between the two groups;moreover,the levels of Myo,cTnI and hs-CRP were compared at different times and between patients with different prognoses in the research group.The diagnostic positive rate of each index and the correlation of each index with acute myocardial infarction were analyzed.Results The levels of Myo,cTnI and hs-CRP in serum in the research group were higher than those in the control group(P<0.05).The levels of Myo,cTnI and hs-CRP in serum in patients with acute myocardial infarction in the research group were high at the time of admission,which showed a downward trend with the prolongation of the treatment time after admission.In the study group,the levels of serum Myo,cTnI and hs-CRP in patients with poor prognosis were higher than those in patients with good prognosis(P<0.05).Among the 120 patients with acute myocardial infarction,the diagnostic accuracy of combination of the three indicators(97.50%,117/120)was higher than that of Myo(83.33%,108/120),cTnI(87.50%,105/120)and hs-CRP(89.17%,107/120),P<0.05.The levels of Myo,cTnI,hs-CRP were positively correlated with the prognosis of acute myocardial infarction(r=0.75,0.35,0.42;all P<0.05).Conclusions The combined detection of Myo,cTnI and hs-CRP has a certain diagnostic value for acute myocardial infarction,and it can judge the prognosis of patients.