加味黄芪建中汤联合西药治疗消化性溃疡脾胃虚寒证临床研究

Clinical Study on Modified Huangqi Jianzhong Decoction Combined with Western Medicine for Peptic Ulcer with Spleen-Stomach Deficiency Cold Syndrome

目的:观察加味黄芪建中汤联合西药治疗消化性溃疡脾胃虚寒证的临床疗效。方法:采用随机数字表法将89例消化性溃疡脾胃虚寒证患者分为对照组(45例)与试验组(44例)。对照组给予常规西药治疗,试验组在对照组基础上联用加味黄芪建中汤治疗。比较2组治疗前后中医证候评分、溃疡面积及血清免疫球蛋白、炎症因子水平;比较2组临床疗效、幽门螺杆菌(Hp)根除率及不良反应发生率。结果:试验组总有效率95.45%,高于对照组77.78%(P<0.05)。治疗后,2组中医证候评分、溃疡面积及血清降钙素原(PCT)、白细胞介素-6 (IL-6)、超敏C-反应蛋白(hs-CRP)水平较治疗前降低(P<0.05),且试验组治疗后中医证候评分、溃疡面积、炎症因子水平低于对照组(P<0.05)。2组治疗后免疫球蛋白G (IgG)、免疫球蛋白A (IgA)、免疫球蛋白M (IgM)水平均较治疗前升高(P<0.05),且试验组治疗后上述免疫球蛋白水平高于对照组(P<0.05)。2组Hp根除率比较,差异无统计学意义(P>0.05)。试验组不良反应发生率4.55%,低于对照组26.67%(P<0.05)。结论:加味黄芪建中汤联合西药治疗消化性溃疡脾胃虚寒证疗效确切,能够提高患者免疫水平,减少炎症反应,缩小溃疡面积,安全性较高。

Objective:To observe the clinical effect of Modified Huangqi Jianzhong Decoction combined with western medicine for peptic ulcer with spleen-stomach deficiency cold syndrome.Methods:A total of 89 cases of patients with peptic ulcer with spleen-stomach deficiency cold syndrome were divided into the control group and the trial group according to the random number table method,with 45 and 44 cases in each group respectively.The control group was treated with routine western medicine,and the trial group was additionally treated with Modified Huangqi Jianzhong Decoction based on the treatment of the control group.Traditional Chinese medicine(TCM)syndrome scores,ulcer area,and the levels of immunoglobulin and inflammatory factors in serum were compared before and after treatment between the two groups.The clinical effects,the eradication rates of Helicobacter pylori(Hp)and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate was 95.45%in the trial group,higher than that of 77.78%in the control group(P<0.05).After treatment,the TCM syndrome scores,ulcer area and the levels of procalcitonin(PCT),interleukin-6(IL-6),and hypersensitive C-reactive protein(hs-CRP)in serum in the two groups were decreased when compared with those before treatment(P<0.05),and the TCM syndrome score,ulcer area,and inflammatory factor levels in the trial group were lower than those in the control group(P<0.05).After treatment,the levels of immunoglobulin G(IgG),immunoglobulin A(IgA),and immunoglobulin M(IgM)in the two groups were increased when compared with those before treatment(P<0.05),and the above immunoglobulin levels in the trial group were higher than those in the control group(P<0.05).There was no significant difference being found in the comparison of Hp eradication rates between the two groups(P>0.05).The incidence of adverse reactions in the trial group was 4.55%,lower than that of 26.67%in the control group(P<0.05).Conclusion:Modified Huangqi Jianzhong Decoction combined with western medicine has a definite curative effect in the treatment of peptic ulcer with spleen-stomach deficiency cold syndrome,which can improve the immune levels of patients and reduce inflammatory responses and ulcer area,with high safety.