参芎葡萄糖注射液联合低分子肝素治疗急性脑梗死临床研究

Clinical Study on Senate Ligusticum Glucose Injection Combined with Low Molecular Weight Heparin for Acute Cerebral Infarction

目的:观察参芎葡萄糖注射液联合低分子肝素治疗急性脑梗死(ACI)的临床疗效。方法:按照随机数字表法将63例ACI患者分为A组31例与B组32例。A组采用低分子肝素治疗,B组在A组基础上联合参芎葡萄糖注射液治疗。2组均治疗15 d。比较2组治疗前后中医证候积分、大脑平均血流速度、Barthel指数和美国国立卫生研究院卒中量表(NIHSS)评分,比较2组临床疗效和不良反应。结果:B组总有效率96.88%,高于A组77.42%(P<0.05)。治疗前,2组中医证候积分比较,差异无统计学意义(P>0.05)。治疗后,2组头晕目眩、半身不遂、偏身麻木、舌苔白腻中医证候积分均降低(P<0.05),且B组低于A组(P<0.05)。治疗前,2组Barthel指数、NHISS评分比较,差异无统计学意义(P>0.05);治疗后,2组Barthel指数评分升高(P<0.05),NHISS评分降低(P<0.05),且B组Barthel指数评分高于A组(P<0.05),NHISS评分低于A组(P<0.05)。治疗前,2组大脑中动脉、前动脉和后动脉平均血流速度比较,差异均无统计学意义(P>0.05);治疗后,2组大脑中动脉、前动脉和后动脉平均血流速度均增大(P<0.05),且B组大于A组(P<0.05)。B组不良反应总发生率低于A组(χ^(2)=6.907,P=0.009)。结论:参芎葡萄糖注射液联合低分子肝素治疗ACI患者疗效理想,能改善患者症状,提高其神经功能和生活质量,调节脑血流速度,更具安全性。

Objective:To observe the clinical effect of Senate Ligusticum Glucose Injection combined with low molecular weight heparin for acute cerebral infarction(ACI).Methods:A total of 63 cases of ACI patients were divided into the A group and the B group according to the random number table method,with 31 and 32 cases in each group respectively.The A group was treated with low molecular weight heparin,and the B group was treated with Senate Ligusticum Glucose Injection based on the treatment of the A group.Both two groups were treated for 15 days.Before and after treatment,traditional Chinese medicine(TCM)syndrome scores,average cerebral blood flow velocity,Barthel Index,National Institutes of Health Stroke Scale(NIHSS)scores were compared between the two groups.The clinical effects and adverse reactions were compared between the two groups.Results:The total effective rate was 96.88%in the B group,higher than that of 77.42%in the A group(P<0.05).Before treatment,there was no significant difference being found in the comparison of TCM syndrome scores between the two groups(P>0.05).After treatment,the TCM syndrome scores including giddy and dazzled,hemiplegia,hemianesthesia,and white greasy tongue coating in the two groups were decreased(P<0.05),and the scores in the B group were lower than those in the A group(P<0.05).Before treatment,there was no significant difference being found in the comparison of scores of Barthel Index and NIHSS between the two groups(P>0.05).After treatment,scores of Barthel Index in the two groups were increased when compared with those before treatment(P<0.05),NHISS scores were decreased(P<0.05);the score of Barthel Index in the B group was higher than that in the A group(P<0.05),and the NIHSS score was lower than that in the A group(P<0.05).Before treatment,there was no significant difference being found in the comparison of mean blood velocity of middle artery,anterior artery,and posterior artery between the two groups(P>0.05).After treatment,the mean blood velocity of middle artery,anterior artery,and posterior artery in the two groups were increased(P<0.05),and the ones in the B group were larger than those in the A group(P<0.05).The total incidence of adverse reactions in the B group was lower than that in the A group(χ^(2)=6.907,P=0.009).Conclusion:The combination of Senate Ligusticum Glucose Injection and low molecular weight heparin has an ideal curative effect on ACI patients,which can improve symptoms,neurological function and quality of life,and regulate cerebral blood flow velocity,which is safer.