银杏内酯注射液联合常规西药治疗缺血性脑卒中临床研究

Clinical Study on Ginkgolides Injection Combined with Routine Western Medicine for Ischemic Stroke

目的:观察银杏内酯注射液联合常规西药治疗缺血性脑卒中的临床疗效。方法:选择79例缺血性脑卒中患者,采用随机数字表法分为对照组39例和观察组40例。对照组给予常规西药治疗,观察组在对照组基础上加银杏内酯注射液治疗。2组均治疗14 d。评价2组临床疗效,比较2组治疗前后血脑屏障功能、脑损伤标记物、神经功能缺损情况及认知功能、血小板功能。结果:观察组总有效率为95.00%,高于对照组76.92%(P<0.05)。治疗后,2组脑脊液白蛋白、血清白蛋白及血脑屏障指数较治疗前降低(P<0.05),且观察组脑脊液白蛋白、血清白蛋白及血脑屏障指数低于对照组(P<0.05)。治疗后,2组神经元特异性烯醇化酶(NSE)、S100钙结合蛋白B (S100B)水平较治疗前降低(P<0.05),且观察组NSE、S100B水平低于对照组(P<0.05)。治疗后,2组神经功能缺损评分量表(NIHSS)评分较治疗前降低,简易智力状态检查量表(MMSE)评分较治疗前升高(P<0.05);且观察组NIHSS评分低于对照组,MMSE评分高于对照组(P<0.05)。治疗后,2组血小板黏附率及血小板聚集率较治疗前降低(P<0.05),且观察组血小板黏附率及血小板聚集率低于对照组(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:银杏内酯注射液联合常规西药治疗缺血性脑卒中可以改善患者血脑屏障功能,降低脑损伤,改善患者认知功能,具有良好的安全性。

Objective:To observe the clinical effect of Ginkgolides Injection combined with routine western medicine for ischemic stroke.Methods:A total of 79 cases of patients with ischemic stroke were selected and divided into the control group and the observation group according to the random number table method,with 39 and 40 cases in each group respectively.The control group was treated with routine western medicine,and the observation group was additionally treated with Ginkgolides Injection based on the treatment of the control group.Both groups were treated for 14 days.The clinical effects in the two groups were evaluated.Before and after treatment,blood brain barrier function,brain injury markers,neurological impairment,cognitive function,and platelet function were compared between the two groups.Results:The total effective rate was 95.00%in the observation group,higher than that of 76.92%in the control group(P<0.05).After treatment,the indexes of cerebrospinal fluid albumin,serum albumin,and blood-brain barrier in the two groups were decreased when compared with those before treatment(P<0.05),and the above indexes in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of neuron-specific enolase(NSE)and S100 calcium-binding protein B(S100B)in the two groups were decreased when compared with those before treatment(P<0.05),and the levels of NSE and S100B in the observation group were lower than those in the control group(P<0.05).After treatment,the scores of National Institute of Health Stroke Scale(NIHSS)in the two groups were decreased when compared with those before treatment,and the scores of Mini-Mental State Examination(MMSE)were increased when compared with those before treatment(P<0.05);NIHSS score in the observation group was lower than that in the control group,and MMSE score was higher than that in the control group(P<0.05).After treatment,platelet adhesion rates and platelet aggregation rates in the two groups were decreased when compared with those before treatment(P<0.05),and the platelet adhesion rate and platelet aggregation rate in the observation group were lower than those in the control group(P<0.05).There was no significant difference being found in the comparison of the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Ginkgolides Injection combined with routine western medicine for ischemic stroke can improve the blood-brain barrier function,reduce brain injury,and improve the cognitive function of patients with good safety.