针刺联合加味四君子汤治疗慢性咽炎临床研究

Clinical Study on Acupuncture Combined with Modified Sijunzi Decoction for Chronic Pharyngitis

目的:观察针刺联合加味四君子汤对慢性咽炎患者呼吸道黏膜免疫功能、炎症因子的影响。方法:选取156例慢性咽炎患者,按随机数字表法分为汤药组、针刺组和联合组各52例。汤药组给予加味四君子汤治疗,针刺组给予针刺治疗,联合组给予针刺联合加味四君子汤治疗。3组均治疗3个月。比较3组治疗前后中医证候评分,记录患者临床症状改善时间,检测分泌性免疫球蛋白A (sIgA)、超敏C-反应蛋白(hs-CRP)、白细胞介素-6 (IL-6)、肿瘤坏死因子-α (TNF-α)水平。结果:治疗后,3组咽干咽痛、恶心干呕、舌苔黄燥、咽黏膜状态评分均较治疗前降低(P<0.05),且联合组咽干咽痛、恶心干呕、舌苔黄燥、咽黏膜状态评分均低于汤药组和针刺组(P<0.05)。治疗后,联合组声音嘶哑消失时间、咽喉干痒消失时间、咽喉疼痛消失时间、黏膜充血消失时间均早于汤药组和针刺组(P<0.05)。治疗后,3组sIgA水平较治疗前升高(P<0.05),联合组sIgA水平高于汤药组和针刺组(P<0.05)。治疗后,3组hs-CRP、IL-6、TNF-α水平均较治疗前降低(P<0.05),联合组hs-CRP、IL-6、TNF-α均低于汤药组和针刺组(P<0.05)。结论:针刺联合加味四君子汤治疗慢性咽炎能改善患者的临床症状,提高呼吸道黏膜免疫功能,减轻机体炎症反应。

Objective:To observe the effect of acupuncture combined with Modified Sijunzi Decoction on immune function and inflammatory factors of respiratory epithelium in patients with chronic pharyngitis.Methods:A total of 156 cases of patients with chronic pharyngitis were selected and divided into the decoction group,the acupuncture group,and the combination group according to the random number table method,with 52 cases in each group.The decoction group was treated with Modified Sijunzi Decoction,the acupuncture group was treated with acupuncture,and the combination group was treated with acupuncture combined with Modified Sijunzi Decoction.The three groups were treated for 3 months.Traditional Chinese medicine syndrome scores were compared before and after treatment between the two groups.The time of clinical symptom improvement was recorded.The levels of secretory immunoglobulin A(sIgA),high-sensitivity C-reactive protein(hs-CRP),interleukin 6(IL-6),and tumor necrosis factor-α(TNF-α)were detected.Results:After treatment,the scores of dry and sore throat,nausea and belching,yellow and dry tongue coating,and pharyngeal mucosal condition in the three groups were decreased when compared with those before treatment(P<0.05),and the above scores in the combination group were lower than those in the decoction group and the acupuncture group(P<0.05).After treatment,the disappearance time of hoarse voice,dry throat and itching,sore throat and mucous membrane congestion in the combination group was earlier than that in the decoction group and the acupuncture group(P<0.05).After treatment,the levels of sIgA in the three groups were increased when compared with those before treatment(P<0.05),and the level in the combination group was higher than those in the decoction group and the acupuncture group(P<0.05).After treatment,the levels of hs-CRP,IL-6,and TNF-αin the three groups were decreased when compared with those before treatment(P<0.05),and the three levels in the combination group were lower than those in the decoction group and the acupuncture group(P<0.05).Conclusion:Acupuncture combined with Modified Sijunzi Decoction for chronic pharyngitis can improve the clinical symptoms,enhance the immune function of respiratory epithelium,and reduce inflammatory responses of the body.