艾灸联合克拉霉素治疗慢性鼻窦炎临床研究

Clinical Study on Moxibustion Combined with Clarithromycin for Chronic Sinusitis

目的:观察艾灸联合克拉霉素治疗慢性鼻窦炎的临床疗效。方法:选取慢性鼻窦炎患者140例,按随机数字表法分为对照组和观察组各70例。对照组采用克拉霉素片治疗,观察组在对照组基础上加用艾灸疗法。2组疗程均为4周。比较2组治疗前后视觉模拟评分法(VAS)评分、Lund-Mackay评分、LundKennedy评分、中医证候评分、纤毛清除速度(MTR)和纤毛清除率(MCC),评价2组临床疗效,观察不良反应发生情况。结果:观察组总有效率为91.43%,高于对照组72.86%(P<0.05)。治疗后,2组鼻塞、流涕、头面胀痛、嗅觉减退、咳嗽评分较治疗前降低(P<0.05),且观察组鼻塞、流涕、头面胀痛、嗅觉减退、咳嗽评分均低于对照组(P<0.05)。治疗后,2组VAS评分、Lund-Mackay评分及Lund-Kennedy评分均较治疗前下降(P<0.05),且观察组VAS评分、Lund-Mackay评分及Lund-Kennedy评分均低于对照组(P<0.05)。治疗后,2组MTR、MCC均较治疗前升高(P<0.05),且观察组MTR、MCC均高于对照组(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:艾灸联合克拉霉素治疗慢性鼻窦炎可有效减轻患者临床症状,改善鼻黏膜纤毛清除功能,提高患者的生活质量。

Objective:To observe the clinical effect of moxibustion combined with Clarithromycin for chronic sinusitis.Methods:A total of 140 cases of patients with chronic sinusitis were selected and divided into the control group and the observation group according to the random number table method,with 70 cases in each group.The control group was treated with clarithromycin,and the observation group was additionally treated with moxibustion based on the treatment of the control group.Both groups were treated for 4 weeks.The scores of Visual Analogue Scale(VAS),Lund-Mackay,Lund-Kennedy,traditional Chinese medicine syndrome scores,mucociliary transport rate(MTR),and mucociliary clearance(MCC)were compared before and after treatment between the two groups.Clinical effects were evaluated in the two groups,and the incidence of adverse reactions was observed.Results:The total effective rate was 91.43%in the observation group,higher than that of 72.86%in the control group(P<0.05).After treatment,the scores of nasal congestion,runny nose,swelling and pain on the head and face,hyposmia,and cough in the two groups were decreased when compared with those before treatment(P<0.05),and the above scores in the observation group were lower than those in the control group(P<0.05).After treatment,the scores of VAS,Lund-Mackay,and Lund-Kennedy in the two groups were decreased when compared with those before treatment(P<0.05),and the scores of VAS,Lund-Mackay,and Lund-Kennedy in the observation group were lower than those in the control group(P<0.05).After treatment,MTR and MCC in the two groups were increased when compared with those before treatment(P<0.05),and MTR and MCC in the observation group were higher than those in the control group(P<0.05).There was no significant difference being found in the comparison of the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Moxibustion combined with Clarithromycin for chronic sinusitis can effectively alleviate clinical symptoms and improve nasal mucociliary clearance function and the quality of life of the patients.