中药护膝治疗膝骨关节炎临床研究

Clinical Study on Kneecaps with Chinese Medicine for Knee Osteoarthritis

目的:观察中药护膝治疗膝骨关节炎(KOA)的临床效果。方法:选择120例KOA患者为对象进行回顾性分析,根据治疗方法不同分为对照组、试验A组、试验B组各40例。3组均口服塞来昔布胶囊消炎止痛,试验A组采用中药护膝热熨敷,试验B组采用普通艾盐包热熨敷。3组均治疗3周。比较3组治疗前、治疗7 d、治疗14 d的疼痛视觉模拟评分法(VAS)评分、骨性关节炎指数量表(WOMAC)评分、Lysholm指数评分,并比较3组临床疗效及不良反应发生情况。结果:治疗前,3组VAS评分比较,差异无统计学意义(P>0.05);治疗7 d、治疗14 d,3组VAS评分均逐渐下降(P<0.05),且试验A组低于试验B组(P<0.05),试验B组低于对照组(P<0.05)。治疗前,3组WOMAC评分比较,差异无统计学意义(P>0.05);治疗7 d、治疗14 d,3组WOMAC评分均逐渐下降(P<0.05),且试验A组低于试验B组(P<0.05),试验B组低于对照组(P<0.05)。治疗前,3组Lysholm指数评分比较,差异无统计学意义(P>0.05);治疗7 d、治疗14 d,3组Lysholm指数评分逐渐升高(P<0.05),且试验A组高于试验B组(P<0.05),试验B组高于对照组(P<0.05)。试验A组治疗总有效率97.50%,高于试验B组80.00%(P<0.05);试验B组总有效率高于对照组77.50%(P<0.05)。3组均未发生明显不良反应。结论:中药护膝治疗KOA患者能有效减轻膝关节疼痛,改善膝关节功能,且安全性高。

Objective:To observe the clinical effect of kneecaps with Chinese medicine on knee osteoarthritis(KOA).Methods:A total of 120 KOA patients were given retrospective analysis and divided into the control group,the trial group A and the trial group B according to different treatment methods,with 40 cases in each group.The three groups were given oral administration of Celecoxib Capsules for relieving inflammation and pain,the trial group A was treated with hot compress of kneecaps with Chinese medicine and the trial group B was given hot compress of common moxa salt package.Both three groups were treated for 3 weeks.The scores of Visual Analogue Scale(VAS)for pain,Western Ontario and McMaster Universities Arthritis Index(WOMAC)and Lysholm before treatment,and at the seventh and fourteenth days of treatment were compared between the three groups;the clinical effects and incidence of adverse reactions were compared between the three groups.Results:Before treatment,there was no significant difference being found in the comparison of VAS score between the three groups(P>0.05);at the seventh and fourteenth days of treatment,the VAS scores in the three groups were gradually decreased(P<0.05),the VAS score in the trial group A was lower than that in the trial group B(P<0.05)and the VAS score in the trial group B was lower than that in the control group(P<0.05).Before treatment,there was no significant difference being found in the comparison of WOMAC score between the three groups(P>0.05);at the seventh and fourteenth days of treatment,the WOMAC scores in the three groups were gradually decreased(P<0.05),the WOMAC score in the trial group A was lower than that in the trial group B(P<0.05)and the WOMAC score in the trial group B was lower than that in the control group(P<0.05).Before treatment,there was no significant difference being found in the comparison of Lysholm score between the three groups(P>0.05);at the seventh and fourteenth days of treatment,the Lysholm scores in the three groups were gradually increased(P<0.05),the Lysholm score in the trial group A was higher than that in the experiment group B(P<0.05)and the Lysholm score in the trial group B was higher than that in the control group(P<0.05).The total effective rate was 97.50%in the trial group A,higher than that of 80.00%in the trial group B(χ^(2)=6.134,P=0.013);the total effective rate in the trial group B was higher than that of 77.50%in the control group(χ2=0.075,P=0.785).There was no obvious adverse reaction in the three groups.Conclusion:The kneecaps with Chinese medicine for KOA can effectively mitigate the knee pain and improve the function of knees with good safety.