重组人促红细胞生成素联合还原型谷胱甘肽对尿毒症贫血患者贫血指标及氧化应激反应的影响

Effect of Recombinant Human Erythropoietin Combined with Reduced Glutathione on Anemia Index and Oxidative Stress Response in Patients with Uremia Anemia

目的研究重组人促红细胞生成素(rhEPO)联合还原型谷胱甘肽(GSH)对尿毒症贫血患者贫血指标及氧化应激反应的影响。方法以2020年1月-2022年3月余干楚东医院收治的70例尿毒症贫血患者为研究对象,按照随机数字表法分为对照组(35例)与观察组(35例)。两组均接受血液透析治疗,对照组另给予rhEPO治疗,观察组在其基础上联合GSH治疗,比较两组贫血疗效、贫血指标[红细胞计数(RBC)、红细胞比容(HCT)、血红蛋白(Hb)]、氧化应激指标[超氧化物歧化酶(SOD)、丙二醛(MDA)]、营养指标[血浆白蛋白(TP)、血清转铁蛋白(TRF)]、不良反应。结果观察组贫血治疗有效率高于对照组(P<0.05);两组治疗后RBC、HCT、Hb指标高于治疗前,且观察组RBC、Hb、HCT指标高于对照组(P<0.05);两组治疗后SOD指标高于治疗前,MDA指标低于治疗前,且观察组SOD高于对照组,MDA低于对照组(P<0.05);两组治疗后TP、TRF水平高于治疗前,且观察组TP、TRF水平高于对照组(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论rhEPO联合GSH具有良好的贫血治疗效果,可纠正尿毒症贫血患者的贫血指标,减轻其氧化应激反应,改善其营养状态,且不良反应少。

Objective To study the effect of recombinant human erythropoietin(rhEPO)combined with reduced glutathione(GSH)on anemia index and oxidative stress in patients with uremic anemia.Methods A total of 70 patients with uremic anemia admitted to Yugan Chudong Hospital from January 2020 to March 2022 were selected as research objects,and they were divided into control group(35 patients)and observation group(35 patients)by random number table method.Both groups received hemodialysis treatment,the control group was treated with rhEPO,and the observation group was treated with GSH on the basis of the control group.The anemia efficacy,anemia indicators[red blood cell count(RBC),hematocrit(HCT),hemoglobin(Hb)],oxidative stress indicators[superoxide dismutase(SOD),malondialdehyde(MDA)],nutritional indicators[plasma albumin(TP),serum transferrin(TRF)],adverse reactions were compared between the two groups.Results The effective rate of anemia treatment in the observation group was higher than that in the control group(P<0.05).The levels of RBC,HCT and Hb in the two groups after treatment were higher than those before treatment,and the levels of RBC,Hb and HCT in the observation group were higher than those in the control group(P<0.05).The level of SOD in the two groups after treatment was higher than that before treatment,and the level of MDA was lower than that before treatment,while the level of SOD in the observation group was higher than that in the control group,and the level of MDA was lower than that in the control group(P<0.05).After treatment,the levels of TP and TRF in the two groups were higher than those before treatment,and the levels of TP and TRF in the observation group were higher than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion rhEPO combined with GSH has a good therapeutic effect on anemia,which can correct the anemia index of uremic anemia patients,reduce their oxidative stress reaction,improve their nutritional status,and have fewer adverse reactions.