丁苯酞联合活血化瘀汤治疗脑梗死的临床效果

Clinical Effect of Butylphthalide Combined With Huoxue Huayu Decoction in the Treatment of Cerebral Infarction

目的探讨丁苯酞联合活血化瘀汤在脑梗死患者中的疗效和安全性。方法抽取临沂市中医医院2021年1月—2023年1月收治的90例脑梗死患者作为研究对象,根据随机数字表法将其分为对照组(45例,采取丁苯酞治疗)和试验组(45例,采取丁苯酞联合活血化瘀汤治疗)。对比两组患者治疗前后炎症因子指标、治疗有效率和用药安全性。结果治疗前,两组炎症因子水平比较,差异无统计学意义(P>0.05);治疗后,两组患者白细胞介素-6(interleukin-6,IL-6)指标、超敏C反应蛋白(hypersensitive C-reactive protein,hs-CRP)指标、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)均显著下降,且试验组低于对照组,差异有统计学意义(P<0.05);试验组治疗总有效率为97.78%,明显高于对照组的77.78%(P<0.05);试验组患者不良反应总发生率与对照组比较,差异无统计学意义(P>0.05)。结论丁苯酞联合应用活血化瘀汤治疗脑梗死效果肯定,可有效降低炎症因子水平,改善患者神经功能,抑制患者病情发展,安全性高。

Objective To explore the efficacy and safety of butylphthalide combined with Huoxue Huayu decoction in patients with cerebral infarction.Methods A total of 90 patients with cerebral infarction admitted to Linyi Traditional Chinese Medicine Hospital from January 2021 to January 2023 were selected as the objects of this study.According to random number table method,they were divided into control group(45 cases,treated with butylphthalein)and experimental group(45 cases,treated with butylphthalein combined with Huoxue Huayu decoction).Inflammatory factors,effective rate and safety of medication before and after treatment were observed and analyzed.Results Before treatment,there was no significant difference in the levels of inflammatory factors between two groups(P>0.05).After treatment,the interleukin-6(IL-6)index,hypersensitive C-reactive protein(hs-CRP)and tumor necrosis factor-α(TNF-α)all decrease significantly,and the experimental group shows lower necrosis than the control group,with statistical significance(P<0.05).The total effective rate of the experimental group was 97.78%,which was significantly higher than that of the control group(77.78%)(P<0.05).There was no significant difference in the total incidence of adverse reactions between the experimental group and the control group(P>0.05).Conclusion The combination application of butylphthalide and Huoxue Huayu decoction has a significant effect on reducing inflammatory factors in patients with cerebral infarction,improving their neurological function,inhibiting the development of their condition,and has high safety.