持续大剂量胰岛素泵注射对小儿糖尿病的临床效果及对不良反应的影响

Clinical Effect and Adverse Reaction of Continuous High-dose Insulin Pump Injection on Children with Diabetes

目的 分析持续大剂量胰岛素泵注射对小儿糖尿病的临床效果及对不良反应的影响。方法 选取2021年6月至2022年6月山东省邹平市人民医院收治的小儿糖尿病患者62例,按照随机数字表法分为对照组、研究组,各31例。给予对照组患儿常规计量胰岛素泵治疗,给予研究组患儿大剂量胰岛素泵注射治疗,分析两组患儿临床指标、血脂指标[低密度脂蛋白胆固醇(LDL-C)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)]、血糖指标[糖化血红蛋白(GHb)、餐后2 h血糖(2 h PBG)、空腹血糖(FPG)],分析两组患儿治疗有效率及不良反应发生情况。结果 与对照组相比,研究组血糖下降速度、血糖达标时间均较低,具有统计学差异(P>0.05);治疗后两组患儿LDL-C、TG水平有所下降,HDL-C水平有所上升,且与对照组相比,研究组患儿LDL-C、TG水平较低,HDL-C水平较高(P<0.05);治疗后两组患儿GHb、2 h PBG、FPG水平有所下降,且与对照组相比,研究组GHb、2 h PBG、FPG水平较低(P<0.05);与对照组相比,研究组治疗总有效率较高,两组相比具有统计学意义(P<0.05);相较于对照组,研究组小儿治疗后不良反应发生情况略高,但两组相比无统计学差异(P>0.05)。结论 给予糖尿病患儿大剂量胰岛素泵治疗,患儿血糖指标以及血脂指标得到较好的改善,有着较好的治疗效果,并且治疗中不良反应发生情况较低。

Objective To analyze the clinical effect and adverse reaction of continuous high-dose insulin pump injection on children with diabetes.Methods A total of 62 pediatric diabetic patients treated in Zouping People's Hospital of Shandong Province from June 2021 to June 2022 were selected and divided into control group and study group according to random number table method,with 31 cases in each group.The children in the control group were given routine dose insulin pump treatment,and the children in the study group were given high-dose insulin pump injection treatment.The clinical indexes,blood lipid indexes(LDL-C,TG,HDL-C)and glycemic index(GHb,2 h PBG and FPG)of the children in the two groups were analyzed.The treatment effectiveness and adverse reactions were analyzed in the two groups.Results Compared with the control group,the rate of blood glucose decline and the time of blood glucose reaching the standard in the study group were lower,with statistical difference(P>0.05);After treatment,the levels of LDL-C and TG in the two groups decreased,and the levels of HDL-C increased.Compared with the control group,the levels of LDL-C and TG in the study group were lower,and the levels of HDL-C were higher(P<0.05);After treatment,the levels of GHB,2 h PBG and FPG in the two groups decreased,and compared with the control group,the levels of GHB,2 h PBG and FPG in the study group were lower(P<0.05);Compared with the control group,the total effective rate of the study group was higher,which was statistically significant(P<0.05);Compared with the control group,the incidence of adverse reactions in the study group was slightly higher,but there was no statistical difference between the two groups(P>0.05).Conclusions Given high-dose insulin pump treatment to children with diabetes,the blood glucose index and blood lipid index of children have been better improved,which has a better therapeutic effect,and the incidence of adverse reactions in treatment is low.