注射用右旋雷贝拉唑钠治疗消化性溃疡合并上消化道出血的临床价值分析

Analysis of the Clinical Value of Dexribeprazole Sodium for Injection in the Treatment of Peptic Ulcer Combined with Upper Gastrointestinal Bleeding

目的 探讨消化性溃疡合并上消化道出血应用右旋雷贝拉唑钠治疗的临床价值。方法 选取古田县总医院消化内科2021年7月至2022年6月收治的消化性溃疡合并上消化道出血患者70例,随机分为对照组和观察组各35例。对照组采用泮托拉唑治疗,观察组在对照组基础上加用右旋雷贝拉唑钠治疗,对比两组疗效、止血效果及不良反应。结果 治疗后,观察组24 h内止血率高于对照组(62.9%vs. 37.1%,P=0.031);察组有效率高于对照组(97.1%vs. 82.9%,P=0.046);两组患者不良反应发生率差异无统计学意义(17.1%vs. 25.7%,P=0.382)。结论 消化性溃疡合并上消化道出血患者采用右旋雷贝拉唑钠治疗,疗效较好,可提升止血效果,安全性良好。

Objective To explore the clinical value of peptic ulcer combined with upper gastrointestinal bleeding treated with dexrazepam sodium.Methods 70 patients with peptic ulcer combined with upper gastrointestinal bleeding admitted to the Department of Gastroenterology of Gutian County General Hospital from July 2021 to June 2022 were selected and randomly divided into 35 cases each in the control group and the observation group.The control group was treated with pantoprazole,and the observation group was treated with dexrazoxane sodium on the basis of the control group,comparing the efficacy,hemostatic effect and adverse reactions of the two groups.Results After treatment,the rate of hemostasis within 24 h in the observation group was higher than that in the control group(62.9%vs.37.1%,P=0.031);the effective rate in the probationary group was higher than that in the control group(97.1%vs.82.9%,P=0.046);the difference in the incidence of adverse reactions between the two groups of patients was not statistically significant(17.1%vs.25.7%,P=0.382).Conclusions Patients with peptic ulcer combined with upper gastrointestinal bleeding were treated with dexrazepam sodium,which had better efficacy,enhanced hemostasis,and had good safety.