摘要
表没食子儿茶素没食子酸酯(Epigallocatechin 3-gallate,EGCG)是一种来源于绿茶提取物的丰富多酚成分,具有多种药理活性。EGCG在帕金森病(Parkinson′s disease,PD)的实验模型中具有多种神经保护作用,成为PD治疗的潜在药物。该文系统总结了EGCG在PD中神经保护的最新进展,重点归纳了其在抗凋亡、抗氧化、抗炎、调节多巴胺生成以及α-突触核蛋白聚集方面的分子机制。该综述强调了EGCG的药理学特征及其对PD的治疗作用,以期为深入研究提供启示意义。
Epigallocatechin 3-gallate(EGCG)is an abundant polyphenolic component originating from green tea extract that has exhibited versatile bioactivities in combating several diseases.During the last decade,EGCG are effective in experimental models of Parkinson′s disease(PD).Several experimental studies suggest the pleiotropic neuroprotective effects,aiding to EGCG as an appealing therapeutic strategy in PD.Therefore,in this review we focus on the effects of EGCG on anti-apoptosis,anti-oxidant,anti-inflammation,modulation of dopamine production,and the aggregation ofα-synuclein.We aim to compile the recent updates and cellular and molecular mechanisms of neuroprotection of EGCG in PD.This review highlights the pharmacological features of EGCG and its therapeutic implications in PD.
作者
丁新玲
孙会艳
李强
王洪权
DING Xin-ling;SUN Hui-yan;LI Qiang;WANG Hong-quan(School of Basic Medicine,Chifeng University,Chifeng Inner Mongolia,Chifeng 024000,China;the Department of Medical,Chifeng University,Chifeng Inner Mongolia,Chifeng 024000,China;Key Laboratory of Human Genetic Diseases in Inner Mongolia,Chifeng Inner Mongolia 024000,China;Dept of Neurology,the Affiliated Hospital of Chifeng University,Chifeng Inner Mongolia 024005,China;Tianjin Medical University Cancer Institute and Hospital,National Clinical Research Center for Cancer,Key Laboratory of Cancer Prevention and Therapy,Tianjin s Clinical Research Center for Cancer,Tianjin 300060,China)
出处
《中国药理学通报》
CAS
CSCD
北大核心
2023年第10期1806-1810,共5页
Chinese Pharmacological Bulletin
基金
内蒙古自然科学基金项目(No 2021MS08131,2021LHMS08024,2020MS08175,2022MS08046)
航天医科科研基金资助项目(No 22020YK04,2021YK05)。
