肿瘤微环境中周细胞参与肿瘤转移的研究进展

Advances in involvement of pericyte in tumour microenvironment in tumour metastasis

周细胞是血管壁细胞的重要组成部分,具有调控血流量、清除或吞噬细胞碎屑等作用,是一种包裹全身毛细血管的收缩细胞。它控制血管通透性并参与血管的发育,是血管生成和血管功能的重要调节者和潜在药物靶点。周细胞也被认为在肿瘤微环境中发挥着关键作用,尤其是在肿瘤生长和远端转移过程中。因此,该文对参与肿瘤血管生成的周细胞与肿瘤转移之间的关系以及靶向周细胞治疗肿瘤进行综述,以期能为后续的研究提供依据。

Pericytes are essential components of vessel mural cells that function to regulate blood flow,clear or phagocytose debris,and are contractile cells enwrapping capillaries throughout the body.It controls vascular permeability and is involved in the development of blood vessels and is an important regulator and potential drug target of angiogenesis and vascular function.Pericytes are also thought to play a key role in the tumor microenvironment,especially during tumor growth and distal metastasis.Therefore,in this review we discuss the relationship between pericytes involved in tumor angiogenesis and tumor metastasis,as well as the use of targeted pericytes to treat tumors,with a view to providing a basis for subsequent studies.