不伴认知功能障碍早期2型糖尿病脑结构改变

Brain Macrostructural Change of Early Stage T2DM Patients without Cognitive Impairment

目的研究不伴认知功能障碍的早期2型糖尿病(T2DM)患者脑皮层厚度及不同皮下核团体积结构改变。方法本研究选取27例不伴认知功能障碍的早期2型糖尿病患者及与之年龄、性别、受教育程度匹配的21例正常对照组,通过3.0T MR扫描仪获取3D-T1WI图像,使用Freesurfer软件对两组间结构图像进行分析处理,评估糖尿病患者大脑皮层厚度及19个不同皮下核团体积结构改变。结果皮层厚度指标T2DM组与正常对照组相比差异无统计学意义,但额顶叶部分脑区皮层厚度有减低趋势;皮下核团T2DM组与正常对照组相比左侧苍白球、丘脑体积减小,差异有统计学意义(P<0.05),余皮下核团体积差异无统计学意义。结论本研究对早期不伴认知功能障碍T2DM患者皮层厚度及皮下核团体积的结构探索,对评估糖尿病早期其脑损害具有一定临床价值。

Objective Using Freesurfer software to segment cortical thickness and different subcortical nucleus volume automatically to detect microstructure changes in early stage of type 2 diabetes mellitus(T2DM)patients without cognitive impairment.Methods27 patients with short-term T2DM without cognitive impairment and 21 health controls matched with their age,sex and education level were selected in this study.3D-T1WI images were acquired by 3.0T MR scanner.structural T1WI images were analyzed and processed by Freesurfer software to evaluate the thickness of cerebral cortex and the volume of 19 subcortical nucleus in early T2DM patients.ResultsThere was no significant difference in cortical thickness between T2DM patients and health controls,but the cortical thickness of some brain regions in the frontal and parietal lobes presented decreasing tendency.The volume of left pallidum and thalamus in T2DM was significantly smaller than that in health control(P<0.05).There was no significant difference in the volume of other subcortical nucleus.ConclusionThis study explored the structure of cortical thickness and volume of subcortical nucleus in early T2DM patients without cognitive impairment,which has certain clinical value for assessing brain damage of early stage T2DM.