钙化性主动脉瓣疾病的发病机制与抗钙化研究进展

Research progress on pathogenesis and anti-calcification of calcified aortic valve disease

随着全球老龄化加剧,钙化性主动脉瓣膜疾病(calcified aortic valve disease, CAVD)已成为继冠心病、高血压之后的第三大心血管疾病。以往认为CAVD是一种退行性病变,但最新的研究提示该病的进展是一个主动的、可调节的过程。CAVD的具体发病机制仍不明确,考虑到瓣膜钙化是多种分子及机制共同参与的复杂过程,本文就主动脉瓣钙化的发病机制及抗钙化的研究进展作一综述。

With theintensification of global aging,calcified aortic valvedisease(CAVD)hasbecomethethird largest cardiovascular disease after coronary heart disease and hypertension.In the past,CAVD was considered a degenerative disease,but the latest research suggested that the progress of CAVD was an active and adjustable process.However,the specific pathogenesis of CAVD was still elusive.Considering that valve calcification was a complex process involved multiple molecules and mechanisms,this article reviewed the research progress of molecular biology mechanisms of aortic valve calcification and anti-calcification.