复方公英散联合戊酸雌二醇对宫腔黏连切除患者术后康复的效果观察

Effect of compound Gongying San combined with estradiol valerate on postoperative rehabilitation of patients with uterine adhesion resection

目的探讨复方公英散联合戊酸雌二醇对宫腔黏连切除患者术后康复效果的影响。方法选取2019年2月—2022年10月青海省人民医院妇科收治的98例宫腔黏连切除患者,按照随机数字表法分为对照组与研究组,每组49例。对照组给予戊酸雌二醇,研究组在对照组基础上使用复方公英散,两组均持续治疗3个月经周期后观察效果。比较两组子宫内膜厚度、宫腔容积、子宫内膜动脉血流动力学、临床疗效、血液流变学、外周血细胞因子变化情况,统计两组药物不良反应情况。结果研究组治疗前后子宫内膜厚度、宫腔容积差值均高于对照组(P<0.05)。研究组治疗前后子宫动脉收缩期峰值流速、搏动指数、阻力指数的差值均高于对照组(P<0.05)。研究组总有效率高于对照组(P<0.05)。研究组治疗前后全血高切黏度、全血低切黏度、红细胞比容的差值高于对照组(P<0.05)。研究组治疗前后转化生长因子β_(1)、基质金属蛋白酶抑制因子-1的差值均高于对照组(P<0.05)。两组总不良反应发生率比较,差异无统计学意义(P>0.05)。结论复方公英散联合戊酸雌二醇治疗宫腔黏连切除患者可以改善子宫内膜厚度、宫腔容积及子宫内膜动脉血流动力学情况,调节血液流变学及外周血细胞因子表达,进而增强治疗效果,安全可靠。

Objective To explore the effect of compound Gongying San combined with estradiol valerate on postoperative rehabilitation of patients with uterine adhesion resection.Methods A total of 98 patients with intrauterine adhesion resection were selected.They were divided into control and study group,49 cases in each group.Control group was given estradiol valerate,and the study group was given compound Gongying SAN on the basis of the control group.Both groups were treated continuously for 3 menstrual cycles to observe the effect.Endometrial thickness,uterine volume,endometrial arterial hemodynamics,clinical efficacy,hemorheology and peripheral blood cytokines were compared between the two groups,and adverse drug reactions were analyzed.Results The differences of endometrial thickness and uterine volume in the study group were higher than those in the control group before and after treatment(P<0.05).The difference values of uterine artery systolic peak velocity(PSV),pulsation index(PI)and resistance index(RI)before and after treatment in the study group were higher than control group(P<0.05).The total effective rate of the study group was higher than that of the control group(P<0.05).The whole blood high tangential viscosity,whole blood low tangential viscosity and RBC tolerance values of the study group before and after treatment were higher than control group(P<0.05).The differences of transforming growth factorβ_(1)(TGF-β_(1))and matrix metalloproteinase inhibitor-1(TIMP-1)before and after treatment in the study group were higher than control group(P<0.05).There was no difference in incidence of total adverse reactions of two groups(P>0.05).Conclusion In the treatment of patients with uterine adhesion resection,compound Gongying powder combined with estradiol valerate can improve endometrial thickness,volume,and endometrial arterial blood flow dynamics,regulate hemorheology and peripheral blood cytokine expression,and thus enhance the therapeutic effect,which is safe and reliable.