基于脑肠轴研究慢性内脏痛的机制

To study the mechanism of chronic visceral pain based on brain-gut axis

慢性内脏痛(chronic visceral pain,CVP)是一种主要涉及胸部、腹部或骨盆区域的内脏器官引起的疼痛。与躯体痛不同,内脏痛发生部位深,定位不明确,缺乏典型的临床表现。由于其病因及病理机制尚不清楚,相关临床治疗方法有限,且疗效不一。目前一般认为其机制可能与脑肠互动异常、急慢性炎症、内脏痛觉过敏、中枢敏化、神经递质异常、缺血、压力等有关。因此本文基于脑肠轴研究参与慢性内脏疼痛的相关作用机制,从肠道微生物、脑肠肽、炎症因子、功能检查学等方面概述慢性内脏痛的可能病因及病理机制,旨在为慢性内脏痛治疗寻求新的治疗靶点和方案。

Chronic visceral pain(CVP)is a type of pain caused by internal organs primarily involving the chest,abdomen,or pelvic region.Different from somatic pain,visceral pain occurs in a deep,unclear location and lacks typical clinical manifestations.Because its etiology and pathological mechanism are still unclear,the relevant clinical treatment methods are limited,and the curative effect is different.At present,it is generally believed that its mechan ism may be related to abnormal brain-intestinal interaction,ac ute and chronic inflammation,visceral hyperalgesia,central sensitization,neurotransmitter abnormalities,ischemia,stress,etc.Therefore,based on the brain-gut axis study on the relevant mechanisms involved in chronic visceral pain,this paper summarized the possible etiology and pathological mechanism of chronic visceral pain from the aspects of gut microbes,brain-gut peptides,inflammatory factors,functional examination,etc.,in order to seek new therapeutic targets and programs for the treatment of chronic visceral pain.