高脂血症患者血浆氧化三甲胺与血脂水平的相关性研究

Correlation Between Plasma Trimethylamine N-Oxide and Lipid Levels in Hyperlipidemic Patients

目的探讨高脂血症患者机体血浆中氧化三甲胺(trimethylamine N-oxide,TMAO)水平和血脂水平的相关性。方法入选2019年3月–2021年3月就诊于新疆医科大学第一附属医院心脏中心的接受冠状动脉造影检查的患者130例。利用稳定同位素液相色谱/质谱法测定患者血浆中TMAO的水平。分析血浆TMAO水平和三酰甘油(triglycerides,TG)、总胆固醇(total cholesterol,TC)、高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-c)和低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL-c)等血脂水平的相关性。结果高血脂患者血浆中TMAO的水平(μmol/L)高于血脂正常的患者(6.73±5.40 vs.3.82±2.65),差异有统计学意义(P<0.05)。控制年龄和体质量指数的影响后,偏相关性分析结果显示,血浆中TMAO的水平与血浆TG(r=0.286,P<0.001)和HDL-c(r=-0.366,P<0.001)的水平有相关性。结论高脂血症患者血浆TMAO的水平和血脂水平具有相关性。

Objective To investigate the correlation between the plasma levels of trimethylamine N-oxide(TMAO)and lipid levels in hyperlipidemic patients.Methods A total of 130 patients who received treatment and underwent coronary angiography at the Heart Center,the First Affiliated Hospital of Xinjiang Medical University between March 2019 and March 2021 were enrolled.Patients'plasma TMAO levels were determined by stable isotope liquid chromatography/mass spectrometry.The correlation between plasma TMAO levels and the levels of lipids,including triglycerides(TG),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),and low-density lipoprotein cholesterol(LDL-C),was analyzed.Results Patients with hyperlipidemia had higher plasma TMAO levels(μmol/L)than patients without hyperlipidemia did(6.73±5.40 vs.3.82±2.65),with the difference being statistically significant(P<0.05).After controlling for the effects of age and body mass index,partial correlation analysis revealed that plasma TMAO levels were positively correlated with plasma TG(r=0.286,P<0.001)and negatively correlated with HDL-C(r=−0.366,P<0.001).Conclusion There is a correlation between plasma TMAO levels and lipid levels in hyperlipidemic patients.