摘要
DEAR EDITOR,Despite the generally increased cancer risk in large,long-lived organisms,cetaceans,among the largest and longest-living mammals,appear to possess a counteracting mechanism.Nevertheless,the genetic basis underlying this mechanism remains poorly understood.The p53 pathway serves as an ideal target for studying the mechanisms behind cancer resistance,as most cancer types have evolved strategies to circumvent its suppressive functions.
基金
supported by the National Key Program of Research and Development,Ministry of Science and Technology of China (2022YFF1301600)
National Natural Science Foundation of China (32070409,32270453 to S.X.X.)
Priority Academic Program Development of Jiangsu Higher Education Institutions to G.Y.and S.X.X.
Qing Lan Project of Jiangsu Province to S.X.X.
