免疫失调与抑郁、痴呆关系的研究进展

Research progress on the relationships of immune disorders with depression and dementia

抑郁症是最常见的精神障碍之一,会增加卒中、心脑血管疾病和痴呆等疾病的发病风险。而某些类型的抑郁症可能是认知障碍的前驱表现。慢性应激和炎症共同损害血管和脑功能,引起小胶质细胞活化和促炎细胞因子增加,导致抑郁和认知障碍,并可能进展成痴呆。抗炎治疗可以改善抑郁症状,抗炎和抗抑郁治疗可以预防炎性抑郁患者认知功能下降。本文针对炎症、抑郁和认知的关系进行综述,拟为炎性抑郁和痴呆的临床研究提供参考。

Depression is one of the most common psychiatric disorders.Depression increases the risk of stroke,cardiovascular disease,and dementia.Certain types of depression may be a harbinger of cognitive impairment.Chronic stress and inflammation jointly compromise vascular and brain functions.The resulting microglial activation and increases in proinflammatory cytokines lead to depression and cognitive impairment,which may progress to dementia.Anti-inflammatory treatments can improve depressive symptoms,and anti-inflammatory and antidepressant treatments may prevent cognitive impairment in patients with inflammatory depression.This paper reviews the relationship between inflammation,depression,and cognition,aiming to provide a reference for the clinical research of inflammatory depression and dementia.