白介素-6在川崎病患儿血清中的表达及变化

Expression and changes of interleukin-6 in serum of children with Kawa saki disease

目的探究白介素-6(IL-6)在川崎病患儿血清中的表达及变化。方法选取2020年1月至2022年1月江西省九江市妇幼保健院住院和门诊收治的60例川崎病患儿作为观察组,并选取同期九江市妇幼保健院的60例健康体检患儿作为对照组,检测两组患儿血清IL-6水平,分析观察组患儿急性期与恢复期IL-6表达变化情况,根据患儿有无冠脉损伤分为冠脉损伤组与非冠脉损伤组,根据患儿有无并发症分为并发症组与无并发症组,比较各组IL-6表达情况,分析IL-6对川崎病的诊断价值。结果观察组IL-6水平高于对照组,差异有统计学意义(P<0.05)。急性期IL-6水平高于恢复期,差异有统计学意义(P<0.05)。冠脉损伤组IL-6水平高于非冠脉损伤组,差异有统计学意义(P<0.05)。并发症组IL-6水平高于非并发症组,差异有统计学意义(P<0.05)。IL-6诊断小儿川崎病敏感度、特异度分别为93.63%、89.45%。川崎病患儿冠状动脉最大内径与急性期、恢复期IL-6水平呈正相关(r=0.426、0.616,P<0.05)。结论IL-6在川崎病患儿血清中呈高表达,与患儿疾病状态密切相关,能够反映冠脉损伤情况,预测并发症风险,具有较高临床价值。

Objective To explore the expression and changes of interleukin-6(IL-6)in serum of children with Kawasaki disease.Methods A total of 60 children with Kawasaki disease admitted to Jiujiang Maternal and Child Health Hospital from January 2020 to January 2022 were selected as the observation group,and 60 healthy children in Jiujiang Maternal and Child Health Hospital during the same period were selected as the control group.The serum IL-6 levels of the two groups of children were detected,and the changes of IL-6 expression in the acute stage and recovery stage of the observation group were analyzed.The children were divided into coronary injury group and non-coronary group according to the presence or absence of coronary artery inury.The children with or without complications were divided into complication group and uncomplicated group.The expression of IL-6 of different group was compared,and the diagnostic value of IL-6 in Kawasaki disease was analyzed.Results The level of IL-6 in observation group was higher than that in control group,the difference was statistically significant(P<0.05).The level of IL-6 in acute stage was higher than that in recovery stage,and the difference was statistically significant(P<0.05).The level of IL-6 in coronary artery injury group was higher than that in non-coronary injury group,the difference was statistically significant(P<0.05).The level of IL-6 in the complication group was higher than that in the non-complication group,and the difference was statistically significant(P<0.05).The sensitivity and specificity of IL-6 in the diagnosis of pediatric Kawasaki disease were 93.63%and 89.45%,respectively.The maximum internal diameter of coronary artery in children with Kawasaki disease was positively correlated with IL-6 levels in acute stage and recovery stage(r=0.426,0.616,P<0.05).Conclusion IL-6 is highly expressed in the serum of children with Kawasaki disease,which is closely related to the disease status of children,it can reflect the coronary artery injury and predict the risk of complications,and has high clinical value.