地黄饮子加减与补阳还五汤治疗中风后失语症的临床观察

Clinical Observation on Modified Dihuang Yinzi and Buyang Huanwu Tang in the Treatment of Poststroke Aphasia

目的:探究地黄饮子加减与补阳还五汤治疗中风后失语症的临床疗效。方法:选取脑中风后失语症患者86例,按随机数字表法分为观察组与对照组,每组43例。两组均给予现代医学常规治疗,对照组给予补阳还五汤治疗,观察组给予补阳还五汤合地黄饮子加减治疗。比较两组临床疗效、功能性语言沟通能力量表(Chinese functional communication profile,CFCP)评分、中国康复研究中心汉语标准失语症检查量表(the Chinese Rehabilitation Research Center Standard Aphasia Examination,CRRCAE)评分、美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale,NIHSS)评分、脑卒中失语患者生活质量量表(the Stroke and Aphasia Quality of Life Scale-39,SAQOL-39)评分、日常生活活动能力(Activities of Daily Living,ADL)评分及不良反应发生率。结果:观察组总有效率[88.37%(38/43)]高于对照组[65.12%(28/43)](P<0.01)。治疗前,两组CFCP各维度评分及总评分和CRRCAE、NIHSS、SAQOL-39及ADL评分比较,差异无统计学意义(P>0.05),治疗前后两组组内比较差异有统计学意义(P<0.05),治疗后两组组间比较,差异也有统计学意义(P<0.05)。观察组不良反应率[9.30%(4/43)]低于对照组[6.98%(3/43)],两组比较差异无统计学意义(P>0.05)。结论:在常规治疗的基础上,相较于服用补阳还五汤治疗,联合服用地黄饮子能更加明显地改善脑卒中失语症患者的神经功能、生活质量和日常生活活动能力,促进语言功能的恢复。

Objective:To explore clinical effects of modified Dihuang Yinzi and Buyang Huanwu Tang in the treatment of poststroke aphasia.Methods:All 86 patients were allocated to the observation group and the control group according to random number table method with 43 cases in each group.Both groups accepted routine treatment in modern medicine,and the control group was treated with Buyang Huanwu Tang,the observation group with Dihuang Yinzi and Buyang Huanwu Tang.To compare clinical effects,CFCP scores,CRRCAE scores,NIHSS scores,SAQOL-39 scores,ADL scores and the incidence of adverse reaction between both groups.Results:Total effective rate of the observation group was[88.37%(38/43)],higher than[65.12%(28/43)]of the control group(P<0.01).Before the treatment,the difference had no statistical meaning in different dimensional scores of CFCP,total scores,CRRCAE,NIHSS,SAQOL-39 and ADL scores between both groups(P>0.05),and the difference had statistical meaning within both groups before and after the treatment(P<0.05),after the treatment,the difference had statistical meaning between both groups(P<0.05).The incidence of adverse reaction of the observation group was[9.30%(4/43)],lower than[6.98%(3/43)]of the control group,and the difference had no statistical meaning between both groups(P>0.05).Conclusion:On the foundation of conventional therapy,than oral administration of Buyang Huanwu Tang,its combination with Dihuang Yinzi could more remarkably improve the patients'neurological function,quality of life and ADL,and promote the recovery of speech function.