图像引导放射治疗对肺癌放射治疗精度的影响研究

Study on the Impact of Image-guided Radiation Therapy on the Accuracy of Lung Cancer Radiation Therapy

目的:分析在肺癌患者放射治疗中对患者采取图像引导放射治疗对治疗精度的影响。方法:选择2019年1月—2021年12月河南宏力医院肿瘤放疗科医治的30例肺癌患者作为研究对象,按照简单随机化分组法,将研究对象分成观察组(15例)和对照组(15例)。比较患者之间的临床疗效、肺功能变化[用力肺活量(FVC)、充分吸气后第一秒呼出气体的量(FEV_(1))及二者的比率(FEV_(1)/FVE)]、肿瘤靶区覆盖率和相应配准区域的偏差面积、比较两组患者治疗后的远期生存率。结果:比较两组患者之间的治疗总有效率,观察组患者的(93.3%)比对照组患者(66.7%)高,差异有统计学意义(χ^(2)=22.111,P<0.05);治疗后,观察组患者的肺功能相关指标(FVC、FEV_(1)、FEV_(1)/FVE)比对照组患者的明显更高,差异有统计学意义(t=35.982、29.487、19.748,P<0.05);观察组患者的靶区附近区域、患侧配准祛瘀与体廓范围的肿瘤靶区覆盖率均比对照组明显更高,差异有统计学意义(t=21.941、6.373、5.586,P<0.05);观察组患者的靶区附近区域、患侧配准祛瘀与体廓范围的偏差面积比对照组患者明显更小,差异有统计学意义(t=53.034、9.585、8.660,P<0.05);观察组患者半年、1年及3年内的远期生存率明显比对照组高,差异有统计学意义(P<0.05)。结论:肺癌患者采取图像引导放射治疗可提升治疗精度,扩大肿瘤覆盖面积,改善肺部功能,延缓病情,提高临床疗效。

Objective:To analyze the impact of image-guided radiation therapy on treatment accuracy when administered to pa⁃tients in lung cancer radiation therapy.Methods:30 lung cancer patients treated in the hospital from January 2019 to December 2021 were selected as the experimental subjects,and the study subjects were divided into an observation group(15 cases)and a control group(15 cases)according to the simple randomization grouping method.The clinical outcomes of patients,changes in lung function(exertional spirometry[FVC],the volume of gas exhaled in the first second after full inspiration[FEV_(1)]and the ratio of the two[FEV_(1)/FVE]),the coverage of the tumor target area and the area of deviation of the corresponding alignment area and the long-term survival rate after treatment were compared.Results:The total effective rate of treatment in the observation group(93.3%)was higher than that in the control group(66.7%),and the difference was statistically significant(χ^(2)=22.111,P<0.05).Af⁃ter treatment,the lung function-related indexes(FVC,FEV_(1),FEV_(1)/FVE)were significantly higher in the observation group than in the control group,with statistically significant differences(t=35.982,29.487,19.748,P<0.05).The coverage rate of tumor target area in the area near the target area,the affected side of the alignment dispel and the body contour range were significantly higher in the observation group than in the control group,and the difference was statistically significant(t=21.941,6.373,5.586,P<0.05).The area of deviation between the area near the target area,the affected side of the alignment dispel and the body contour range was significantly smaller in the observation group than in the control group,and the difference was statistically significant(t=53.034,9.585,8.660,P<0.05).The long-term survival rate in the observation group at six months,one year and three years was significantly higher than that in the control group,and the difference was statistically significant(P<0.05).Conclusion:Im⁃age-guided radiation therapy for lung cancer patients can enhance treatment accuracy,expand tumor coverage,improve lung func⁃tion,delay the disease,and improve clinical outcomes.