卵巢癌合并副肿瘤肾病综合征1例

One case of ovarian cancer-associated paraneoplastic nephrotic syndrome

本文报道滨州医学院附属医院1例以副肿瘤肾病综合征(PNS)为表现的卵巢癌患者。患者主要表现为蛋白尿、血尿及低白蛋白血症。正电子发射计算机断层显像(PET-CT)示:左附件区肿块伴腹腔盆腔多发淋巴结转移。淋巴结活检病理:考虑卵巢高级别浆液性癌转移可能性大。肾脏穿刺活检:膜性肾病Ⅰ期伴局灶球性硬化。在给予抗感染、利尿消肿、护肾、减少尿蛋白等对症治疗后,患者接受了紫杉醇联合顺铂新辅助化疗4个周期,具体剂量:紫杉醇180 mg d1、顺铂400 mg d1。复查血常规、肾功能等检查无明显异常,遂行卵巢癌根治术,术后恢复可。

This article reported one case of ovarian cancer with paraneoplastic nephrotic syndrome(PNS)in Binzhou Medical University Hospital.The patient presented primarily with proteinuria,hematuria,and hypoalbuminemia.The positron emission tomography-computerized tomography(PET-CT)showed a mass in the left adnexa with multiple lymph node metastases in the abdominal and pelvic cavity.Lymph node biopsy pathology considered the possibility of high-grade serous carcinoma metastasis of the ovaries.Renal biopsy showed stageⅠmembranous nephropathy with focal globular sclerosis.After symptomatic treatment such as anti-infection,inducing diuresis to reduce edema,kidney protection,and urine protein reduction,the patient received neoadjuvant chemotherapy with paclitaxel and cisplatin for 4 cycles(paclitaxel 180 mg d1 and cisplatin 400 mg d1).There were no obvious abnormalities in blood routine and renal function tests,radical ovarian cancer was performed,and the recovery was good after surgery.