抗大别班达病毒药物研究进展

Research progress in antiviral drugs against Dabie bandavirus

大别班达病毒(Dabie bandavirus,DBV)是一种新型布尼亚病毒,2009年在中国首次被发现。其引起的发热伴血小板减少综合征(severe fever with thrombocytopenia syndrome,SFTS)属于急性传染病,病死率高达30%。近年来,DBV流行范围逐步扩大,给人类生命健康带来巨大威胁,世界卫生组织已将SFTS列为十大重点传染病之一。迄今为止,尚无特异有效抗DBV药物,SFTS死亡病例逐年增多。本文综述了抗DBV药物研究进展,以期对SFTS的预防和治疗提供更多新的选择。

Severe fever with thrombocytopenia syndrome(SFTS)is an acute infectious disease with a high fatality rate of 30%.This disease is caused by the novel bunyavirus—Dabie bandavirus(DBV),which was first described in China in 2009.The spread of DBV has gradually expanded in recent years,thus posing a major threat to human life and health.SFTS is listed among the top ten priority infectious diseases by the World Health Organization.No antiviral drugs are currently available for this disease,and the number of deaths due to SFTS is increasing each year.This review summarizes research progress in antiviral drugs against DBV,to aid in the development of additional options for the prevention and treatment of SFTS.