两种药物对藏羊前后盘吸虫驱除效果的对比试验

Comparative Study on Effect of TwoKinds of Drugs on Intestinal Amphistomiasis in Tibetan Sheep

青海湖周边的藏羊中出现了精神沉郁、厌食、不跟群等现象,部分藏羊发生顽固性腹泻,伴有体温升高,眼睑、下颌、胸下及腹下部水肿等症状,身体极度虚弱者最终死亡。经流行病学调查和虫卵检查,确诊为羊肝片吸虫和前后盘吸虫混合感染。对于肝片吸虫,目前常用的驱吸虫药物都能取得良好的驱杀效果,但有关前后盘吸虫驱虫药物的效果对比试验报道较少。为了筛选藏羊前后盘吸虫的理想驱虫药物,采用氯硝柳胺片和羟氯扎胺混悬液分别对感染前后盘吸虫的2组藏羊群进行驱虫效果对比试验。结果表明,氯硝柳胺片组平均虫卵减少率为83.45%,羟氯扎胺混悬液平均虫卵减少率为97.06%,羟氯扎胺混悬液效果更加显著(P<0.01)。

The Tibetan sheep around Qinghai Lake occurred mental depression,anorexia,and not following the flock.Some Tibetan sheep occurred intractable diarrhea,accompanied by elevated body temperature,edema symptom of eyelids,lower jaw,lower chest and lower abdomen,etc.Some Tibetan Sheep died of extreme weakness.Through epidemiological investigation and egg examination,it was confirmed that it was caused by the mixed infection of sheep liver fasciola and anterior and posterior discus flukes.For liver fluke,currently commonly used drugs can achieve good repellent effect,but there are few reports on the comparative test of the effect of anterior-posterior discifluke deworming drugs.In order to screen the ideal deworming drugs for anterior-posterior discifluke in Tibetan sheep,clonitsamide tablets and hydroxyclozamide suspension were used to conduct a comparative test of the deworming effect on two groups of Tibetan sheep infected with anterior-posterior discifluke.The results showed that the average egg reduction rate was 83.45%in niclosamide group and 97.06%in hydroxyclozamide suspension.The effect of hydroxyclozamide suspension was more significant(P<0.01).