呼吸道微生态的影响因素及其在支气管肺发育不良中的意义

Influencing factors of respiratory tract microecology and its significance in bronchopulmonary dysplasia

支气管肺发育不良(BPD)是胎龄≤32周早产儿常见的一种并发症,对新生儿呼吸及神经系统发育带来长远的不良影响。BPD病因复杂,是多种因素共同作用导致,呼吸道微生态的多样性及其演变方式的异常会增加BPD患病风险。呼吸道微生态受多种因素的影响,其失衡会增加日后患各系统疾病的风险。文章综述了呼吸道微生态的影响因素及其在BPD中的意义及研究进展,旨在加强二者关系的理解,为BPD的预防及治疗提供新的切入点。

Bronchopulmonary dysplasia(BPD) is a common complication in preterm infants with gestational age ≤32 weeks,which has long-term adverse effects on respiratory and nervous system development of newborns.BPD is caused by the combined action of many factors and its etiology is complex.The diversity of respiratory tract microecology and its abnormal evolution mode will increase the risk of BPD.The microecology of the respiratory tract is affected by many factors,and its imbalance can increase the risk of developing various systemic diseases later in life.This paper reviews the influencing factors of respiratory tract microecology and their significance and research progress in BPD,aiming to strengthen the understanding of their relationship and provide a new entry point for the prevention and treatment of BPD.