NKG2D及其配体治疗胃癌的研究进展

Research progress of NKG2D and its ligands in treatment of gastric cancer

自然杀伤细胞2D(natural killer cell 2D,NKG2D)及其配体在NK细胞识别、启动、增强或抑制淋巴细胞效应功能上发挥着重要作用。近年来,随着肿瘤免疫逃避研究的深入,NK细胞上的NKG2D受体成为一个研究热门。胃癌作为严重影响人类寿命的疾病,其治疗一直是难以突破的难题。近年来,针对癌症的免疫治疗取得了重大突破。NKG2D及其配体可能是一个潜在的免疫治疗方向,故本文综述了NKG2D及其配体治疗胃癌的研究进展。

Natural killer cell 2D(NKG2D)and its ligands play an important role in the recognition,initiation,enhancement,or inhibition of lymphocyte effects in NK cells.In recent years,the NKG2D receptor on NK cells has become a hot research topic with the deepening of tumor immune evasion research.As a serious disease affecting human life span,gastric cancer's treatment has been a difficult problem.In recent years,major breakthroughs have been made in the immunotherapy of cancer.NKG2D and its ligands may be a potential direction of immunotherapy.Therefore,this paper reviews the research progress of NKG2D and its ligands in the treatment of gastric cancer.