原发性干燥综合征生物标志物诊断研究进展

Research progress in biomarker diagnosis of primary Sjögren syndrome

通过梳理国内外研究原发性干燥综合征(pSS)在神经、血液、呼吸、消化系统以及唾液腺、泪腺等组织病理变化中有意义的生物标志物,并在此基础上梳理总结pSS在不同病变系统下具有高度敏感、高度特异性及诊断意义的生物标志物,提出pSS诊断生物标志物研究的现有不足以及建议。以期为pSS的诊断前移,高效靶向治疗及改善预后等方面提供有力理论依据,成功构建pSS异质性细化分层下生物标志物诊疗体系。

This article proposes the existing shortcomings and suggestions in the study of biomarker diagnosis of primary Sjögren syndrome(pSS)by reviewing the significant biomarkers of pSS in the pathological changes of the nervous system,blood system,respiratory system,digestive system,salivary glands,lacrimal glands and other tissues in some studies at home and abroad,and based on this,summarizing the biomarkers with high sensitivity and specificity,and diagnostic significance of pSS in different pathological systems.The biomarker diagnosis and treatment system under the heterogeneity refinement and stratification of pSS has been successfully constructed in order to provide a strong theoretical basis for the early diagnosis of pSS,efficient targeted therapy and improvement of prognosis.