中药丹参治疗心血管疾病的分子机制研究

Study on Molecular Mechanism of Salvia miltiorrhiza in Treating Cardiovascular Diseases

为了利用中药网络药理学方法探究丹参治疗心血管疾病的分子机制,从TCMSP等重要数据库中搜寻丹参的有效药用成分,检索其对应靶点,并从GeneCards等疾病数据库中检索心血管疾病靶点,两者取交集获得共同靶点,利用Cytoscape软件构建“丹参-成分-共同靶点-心血管疾病”网络图谱。通过David数据库对靶点进行GO功能和KEGG信号通路富集分析,并将丹参重要成分与靶点开展分子对接验证。文章发现丹参治疗心血管疾病通过多成分、多靶点、多途径的方式来实现。

The paper aims to investigate the molecular mechanism of Salvia miltiorrhiza in the treatment of cardiovascular diseases by using the network pharmacology approach of traditional Chinese medicine.The effective medicinal components of Salvia miltiorrhiza were searched from important databases such as TCMSP and their corresponding targets were retrieved.The cardiovascular disease targets were searched from GeneCards and other disease databases,and the intersection of the two was used to obtain common targets,and Cytoscape software was utilized to construct a Danshen-component-common target-cardiovascular diseases network map.GO function and KEGG signaling pathway enrichment analyses of the targets were performed through the David database,and molecular docking validation was carried out between the important components of Salvia miltiorrhiza with the identified targets.This paper reveals that the treatment of cardiovascular diseases by Salvia miltiorrhiza involves multifaceted approach,multiple components,multiple targets and multiple pathways.