牛膝醇提物经皮透入治疗骨质疏松症的临床研究

Clinical study on percutaneous penetration of Achyranthes bidentata alcohol extract in the treatment of osteoporosis

目的:观察牛膝醇提物经皮透入治疗骨质疏松症的临床疗效。方法:选取2019年10月—2021年10月深圳市罗湖区中医院收治的经中医辨证分型属肾虚血瘀型诊断为原发性骨质疏松的患者60例,按就诊先后次序随机分为两组:治疗组30例,应用牛膝醇提物经皮透入加碳酸钙D3片口服治疗;对照组30例,单纯应用碳酸钙D3片口服治疗。比较两组患者不同治疗时间节点的骨密度(BMD)、腰椎T值、髋部T值以及Ⅰ型前胶原氨基端前肽(PINP)、骨钙素(BGP)、骨特异性碱性磷酸酶(BLAP)等骨代谢指标。结果:治疗前,两组BMD、腰椎T值、髋部T值、PINP、BGP、BLAP差异无统计学意义(P>0.05)。治疗后6、12个月,治疗组的BMD、腰椎T值、髋部T值、PINP、BGP、BLAP与治疗前差异有统计学意义(P<0.01),对照组上述指标与治疗前差异无统计学意义(P>0.05);治疗组与对照组的上述指标差异有统计学意义(P<0.01)。结论:牛膝醇提物经皮透入治疗骨质疏松症对比单纯西药治疗具有更好的临床疗效,值得在临床进一步推广应用。

Objective To observe the clinical effect of percutaneous penetration of the alcohol extract of Achyranthes bidentata in the treatment of osteoporosis.Methods 60 patients with primary osteoporosis diagnosed as liver and kidney deficiency by TCM syndrome differentiation were randomly divided into two groups according to the order of treatment:30 patients in the treatment group were treated by precutaneous penetration of achyranthes bidentata extract and calcium carbonate D3 tablets;In the control group,30 patients were treated with calcium carbonate D3 tablets orally.The BMD,lumbar T value,hip T value,and bone metabolism indexes such as type I procollagen amino-terminal peptide(PINP),osteocalcin(BGP),bone specific alkaline phosphatase(BLAP)were compared between the two groups at different treatment time points.Results Before treatment,there were no significant differences in BMD,lumbar T-value,hip T-value,PINP,BGP and BLAP between the two groups(P 0.05).After 6 and 12 months of treatment,BMD,T value of lumbar spine,T value of hip,PINP,BGP and BLAP in the treatment group were significantly different from those before treatment(P<0.01),while those in the control group were not significantly different from those before treatment(P>0.05).The above indexes were statistically significant between the treatment group and the control group(P<0.01).Conclusion The percutaneous penetration of the alcohol extract of Achyranthes bidentata has better clinical efficacy than the treatment of western medicine alone in the treatment of osteoporosis,which is worthy of further promotion in clinical practice.