摘要
Due to both the requirements of repeated complex organic synthesis and tedious biochemical verification experiments for the screening of new photosensitizers,the development of a satisfactory photosensitizer with excellent photosensitivity and highly specific response ability is still a great challenge for the accurate imaging localization and the precise photodynamic therapy(PDT)of tumors.Herein,under the help of theoretical calculations,a high-efficient target-activatable aggregation-induced emission(AIE)molecular photosensitizer,TPE-TThPy,is rationally designed and synthesized by the conjugation of tetraphenylethylene(TPE,which is used as the electron donor)and tetrahydropyridine(ThPy,which can be converted to methylpyridine salts as the electron acceptor)using thiophene(T)as the π-bridge.This TPE-TThPy molecule exhibits not only good cellular uptake and mitochondrial targeting ability but also ultra-high monoamine oxidase A(MAO-A)response specificity and excellent photosensitivity when oxidized under the action of MAO-A.The specifically imaging ability and cellular PDT performance of the MOA-A-activatable AIE photosensitizer of TPE-TThPy is demonstrated by using different cell lines and mouse tumor models.The successful development of this MOA-A-activatable AIE photosensitizer also provides insight for the development of single-molecule PDT therapeutic drugs with excellent photosensitivity and highly specific targeting-response ability.
基金
NSFC,Grant/Award Number:21775035
Natural Science Foundation of Hunan Province,Grant/Award Numbers:2020SK2096,2021JJ31137。