血管内皮生长因子、成纤维细胞生长因子、胎盘生长因子、血管生成素与急性脑梗死患者颈动脉颅外段狭窄和斑块的关系研究

A study on the relationship between vascular endothelial growth factor,fibroblast growth factor,placental growth factor,angiopoietin and carotid artery stenosis and plaque in patients with acute cerebral infarction

目的 探讨血管内皮生长因子(VEGF)、成纤维细胞生长因子(FGF)、胎盘生长因子(PLGF)、血管生成素(Ang)与急性脑梗死患者颈动脉颅外段狭窄和斑块的关系。方法 随机抽选本院在2021年6月—2022年6月收治的急性脑梗苏患者128例,以院内检查是否存在颈部动脉颅外段狭窄将其分为狭窄组(n=87)、无狭窄组(n=41),之后根据患者有无斑块将其分为有斑块组(n=90)、无斑块组(n=38),对比组间基线资料,患者狭窄及斑块情况,血清分子与狭窄、斑块的相关性。结果 2组患者体质量、吸烟情况以及高血压对比差异有统计学意义(P<0.05),狭窄组VEGF、FGF、PLGF、Ang水平高于对照组(P<0.05);根据回归系数计算得出,VEGF≥224.36 ng/L、FGF≥304.00 ng/L、PLGF≥11.60 ng/L、Ang≥864.58 ng/L及吸烟史是影响患者颈动脉颅外段出现狭窄的危险因素(P<0.05)。无斑块组血管因子检测指标低于斑块组(P<0.05);根据回归系数计算得出,VEGF≥224.36 ng/L、FGF≥304.00 ng/L、PLGF≥11.60 ng/L是影响患者颈动脉颅外段出现斑块的危险因素(P<0.05)。结论 血管VEGF、FGF、PLGF的增高与急性脑梗死患者颈动脉段狭窄、斑块程度关系密切,同时患者的吸烟史是导致颈动脉颅外段出现狭窄的危险因素,值得做进一步研究。

Objective This paper aims to investigate the relationship between vascular endothelial growth factor(VEGF), fibroblast growth factor(FGF), placental growth factor(PLGF), angiopoietin(Ang) and extracranial carotid artery stenosis and plaque in patients with acute cerebral infarction. Methods A total of 128 cases of acute cerebral infarction patients admitted to our hospital from July 2020 to July 2021 were randomly selected and divided into stenosis group(n=87) and non-stenosis group(n=41) after hospital examination for the presence of extracranial neck artery stenosis. After that, patients were divided into plaque group(n=90) and non-plaque group(n=38) according to the presence or absence of plaque. Baseline data, stenosis and plaque status, and the correlation between serum molecules and stenosis and plaque were compared between the groups. Results There was statistical significance on the differences in body weight, smoking status and hypertension between 2 groups(P<0.05). The levels of VEGF, FGF, PLGF and Ang in stenosis group were higher than those in control group(P<0.05). According to the regression coefficient calculation, VEGF≥224.36 ng/L, FGF≥304.00 ng/L, PLGF≥11.60 ng/L, Ang≥864.58 ng/L and smoking history were the risk factors for the occurrence of carotid artery stenosis(P<0.05). The vascular factor detection index of the non-plaque group was lower than that of the plaque group(P<0.05). According to the regression coefficient calculation, VEGF≥224.36 ng/L, FGF≥304.00 ng/L, PLGF≥11.60 ng/L were the risk factors affecting the occurrence of carotid artery plaques in the extracranial segment of patients(P<0.05). Conclusion The increase of vascular VEGF, FGF, PLGF were closely related to the degree of carotid artery stenosis and plaque in patients with acute cerebral infarction. Meanwhile, smoking history is also risk factors for the occurrence of carotid artery stenosis in the extracranial segment, which is worthy of further study.