辛烯基琥珀酸苦荞糊精酯自聚集特性研究

Study on Aggregation Behavior of Octenyl Succinate Tartary Buckwheat Dextrin

为了将亲水性的苦荞淀粉改性为两亲性高分子,进而提高生物利用率,然后研究其改性糊精的自聚集行为及影响因素。采用辛烯基琥珀酸酐(Octenyl succin in anhydride,OSA)作为改性剂,将苦荞淀粉降解为苦荞糊精,制备辛烯基琥珀酸酐苦荞糊精酯(Octenyl succinyl anhydride tartary buckwheat dextrin,OSATBD)并构建了OSATBD自聚集体,并且从结构因素和环境因素两方面对自聚集行为的影响进行了探究。结果表明,成功改性后的OSATBD形成的自聚集纳米颗粒呈椭球形且分布均匀,粒径在300 nm左右。随着取代度增大,OSATBD的临界聚集浓度(Critical aggregation concentration,CAC)降低,OSATBD自聚集体系中粒子的粒径会减小,但是稳定性得以提升。环境的变化同样会对自聚集行为有一定的影响。在分子质量和取代度一定的前提下,样品浓度的改变对自聚集纳米粒的粒径和分散性都没有太大影响;然而环境p H值的降低和溶液温度的升高都会使得体系分散性下降,纳米粒子粒径也会增大。

In order to modify tartary buckwheat starch into amphiphilic polymer and improve its bioavailability,the self-aggregation behavior and influencing factors of modified dextrin were studied.Using octenyl succin in anhydride(OSA)as modifier,Tartary buckwheat starch was degraded to tartary buckwheat dextrin.Octenyl succinyl anhydride tartary buckwheat dextrin(OSATBD)was prepared and the OSATBD autoaggregate was constructed.And the influence of structural factors and environmental factors on self-aggregation behavior is explored.The results show that the self-aggregation nanoparticles formed by the modified OSATBD are spherical and evenly distributed,and the particle size is about 300 nm.With the increase of substitution degree,the critical aggregation concentration(CAC)of OSATBD decreases,and the particle size of OSATBD self-aggregation system decreases,but the stability of OSATBD self-aggregation system improves.Environmental changes can also have a certain effect on self-aggregation behavior.Under the premise of certain molecular weight and substitution degree,the change of sample concentration has no significant effect on the particle size and dispersion of selfaggregated nanoparticles.However,the decrease of ambient pH and the increase of solution temperature will decrease the dispersion of the system and increase the particle size of nanoparticles.